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Speed of sound ultrasound: comparison with proton density fat fraction assessed with Dixon MRI for fat content quantification of the lower extremity


Ruby, Lisa; Kunut, Ahmet; Nakhostin, Dominik N; Huber, Florian A; Finkenstaedt, Tim; Frauenfelder, Thomas; Sanabria, Sergio J; Rominger, Marga B (2020). Speed of sound ultrasound: comparison with proton density fat fraction assessed with Dixon MRI for fat content quantification of the lower extremity. European Radiology, 30(10):5272-5280.

Abstract

OBJECTIVES
To compare speed of sound (SoS) ultrasound (US) of the calves with Dixon magnetic resonance imaging (MRI) for fat content quantification.
MATERIALS AND METHODS
The study was approved by the local ethics committee. Fifty calf muscles of 35 women (age range 22-81 years) prospectively underwent an US and subsequent MRI (Dixon sequence) examination as well as body weight and impedance fat measurements. SoS (in m/s) was calculated positioning a reflector on the opposite side of a conventional US machine probe with the calf in between. Fiducial nitroglycerin markers were placed on the calf at the reflector and US probe end positions for later registration of the US sonification volumetric section. An automatic segmentation algorithm separated MRI adipose tissue, muscle and bone regions. MRI fat fraction of the entire leg slice (total) and intramuscular and adipose tissue fat fraction were calculated and correlation analysis and correlation coefficient comparison were performed.
RESULTS
Median SoS demonstrated a very strong (r = - 0.83 (95% CI - 0.90; - 0.72); p < 0.001) correlation with MRI total fat fraction, a strong (r = - 0.61 (95% CI - 0.76; - 0.40); p < 0.001) correlation with MRI adipose tissue fat fraction and a moderate (r = - 0.54 (95% CI - 0.71; - 0.31); p < 0.001) correlation with MRI intramuscular fat fraction. Impedance body fat percentage correlated strongly with SoS (r = - 0.72 (95% CI - 0.85; - 0.51); p < 0.001) and MRI total fat fraction (r = 0.61 (95% CI 0.34; 0.78); p < 0.001). For electrical impedance, significantly lower correlations (p = 0.033) were found for MRI total fat fraction compared with SoS.
CONCLUSIONS
Correlations of SoS with Dixon MRI fat fraction measurements were very strong to moderate.
KEY POINTS
• Correlations of speed of sound with Dixon MRI fat fraction measurements of the same body location were very strong to moderate. • Speed of sound measurements showed a high repeatability. • Speed of sound provides a sufficient discrimination range for fat fraction estimates.

Abstract

OBJECTIVES
To compare speed of sound (SoS) ultrasound (US) of the calves with Dixon magnetic resonance imaging (MRI) for fat content quantification.
MATERIALS AND METHODS
The study was approved by the local ethics committee. Fifty calf muscles of 35 women (age range 22-81 years) prospectively underwent an US and subsequent MRI (Dixon sequence) examination as well as body weight and impedance fat measurements. SoS (in m/s) was calculated positioning a reflector on the opposite side of a conventional US machine probe with the calf in between. Fiducial nitroglycerin markers were placed on the calf at the reflector and US probe end positions for later registration of the US sonification volumetric section. An automatic segmentation algorithm separated MRI adipose tissue, muscle and bone regions. MRI fat fraction of the entire leg slice (total) and intramuscular and adipose tissue fat fraction were calculated and correlation analysis and correlation coefficient comparison were performed.
RESULTS
Median SoS demonstrated a very strong (r = - 0.83 (95% CI - 0.90; - 0.72); p < 0.001) correlation with MRI total fat fraction, a strong (r = - 0.61 (95% CI - 0.76; - 0.40); p < 0.001) correlation with MRI adipose tissue fat fraction and a moderate (r = - 0.54 (95% CI - 0.71; - 0.31); p < 0.001) correlation with MRI intramuscular fat fraction. Impedance body fat percentage correlated strongly with SoS (r = - 0.72 (95% CI - 0.85; - 0.51); p < 0.001) and MRI total fat fraction (r = 0.61 (95% CI 0.34; 0.78); p < 0.001). For electrical impedance, significantly lower correlations (p = 0.033) were found for MRI total fat fraction compared with SoS.
CONCLUSIONS
Correlations of SoS with Dixon MRI fat fraction measurements were very strong to moderate.
KEY POINTS
• Correlations of speed of sound with Dixon MRI fat fraction measurements of the same body location were very strong to moderate. • Speed of sound measurements showed a high repeatability. • Speed of sound provides a sufficient discrimination range for fat fraction estimates.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neuroradiology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Radiology, Nuclear Medicine and Imaging
Language:English
Date:October 2020
Deposited On:05 Jun 2020 09:20
Last Modified:08 Sep 2020 01:05
Publisher:Springer
ISSN:0938-7994
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00330-020-06885-8
PubMed ID:32385650

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