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Liquid droplets in the skin


Rai, Arpan; Pelkmans, Lucas (2020). Liquid droplets in the skin. Science, 367(6483):1193-1194.

Abstract

Liquid-liquid phase separation (LLPS), the unmixing of inhomogeneous fluids into two or more phases, is emerging as a paradigm for the formation of a myriad of membraneless compartments inside cells (1, 2). This type of spatial organization, in contrast to membrane-bound compartmentalization, has long lacked unifying principles. However, the physiological relevance of compartmentalization through LLPS inside cells is still poorly understood and often speculative. Additionally, regulatory mechanisms through which cells control and exploit LLPS are still emerging. On page 1210 of this issue, Garcia Quiroz et al. (3) show that keratohyalin granules (KGs) that are formed during epidermal differentiation in the skin are pH-sensitive liquid-like protein condensates. Formation of KGs may be physiologically important because mutations that cause defects in this process are associated with the common skin barrier defect ichthyosis vulgaris.

Abstract

Liquid-liquid phase separation (LLPS), the unmixing of inhomogeneous fluids into two or more phases, is emerging as a paradigm for the formation of a myriad of membraneless compartments inside cells (1, 2). This type of spatial organization, in contrast to membrane-bound compartmentalization, has long lacked unifying principles. However, the physiological relevance of compartmentalization through LLPS inside cells is still poorly understood and often speculative. Additionally, regulatory mechanisms through which cells control and exploit LLPS are still emerging. On page 1210 of this issue, Garcia Quiroz et al. (3) show that keratohyalin granules (KGs) that are formed during epidermal differentiation in the skin are pH-sensitive liquid-like protein condensates. Formation of KGs may be physiologically important because mutations that cause defects in this process are associated with the common skin barrier defect ichthyosis vulgaris.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Multidisciplinary
Uncontrolled Keywords:Multidisciplinary
Language:English
Date:13 March 2020
Deposited On:19 Jun 2020 05:19
Last Modified:29 Jul 2020 15:18
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1126/science.abb0060
PubMed ID:32165570

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