Abstract
Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections are usually mild, and controlled by humoral and cell-based immunity. Reactivation of persistently infected immune cells can lead to a life-threatening disease in immuno-compromised individuals, especially children and transplant recipients. To date, no effective therapy or vaccine against HAdV disease is available to the public. HAdV species C type 2 and 5 are the best-studied of more than 100 HAdV types. They persist in infected cells and release their progeny by host-cell lysis to neighbouring cells and fluids, a process facilitated by the adenovirus death protein (ADP). ADP consists of about 100 amino acids and harbours a single membrane-spanning domain. It undergoes post-translational processing in ER and Golgi compartments, before localizing to the inner nuclear membrane. Here, we discuss the current knowledge on how ADP induces membrane rupture. Membrane rupture is essential for both progression of disease and efficacy of therapeutic viruses in clinical applications, in particular oncolytic therapy.
Item Type: | Journal Article, refereed, original work |
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Communities & Collections: | 07 Faculty of Science > Institute of Molecular Life Sciences |
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Dewey Decimal Classification: | 570 Life sciences; biology |
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Scopus Subject Areas: | Life Sciences > Biophysics
Life Sciences > Structural Biology
Life Sciences > Biochemistry
Life Sciences > Molecular Biology
Life Sciences > Genetics
Life Sciences > Cell Biology |
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Uncontrolled Keywords: | Biophysics, Genetics, Cell Biology, Biochemistry, Molecular Biology, Structural Biology, Adenovirus death protein; apoptosis; cancer therapy; cell death; cell lysis; human adenovirus; membrane rupture; oncolytic viruses; virus egress; virus transmission. |
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Language: | English |
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Date: | 1 June 2020 |
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Deposited On: | 18 Jun 2020 14:28 |
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Last Modified: | 23 Oct 2024 01:39 |
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Publisher: | Wiley-Blackwell Publishing, Inc. |
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ISSN: | 0014-5793 |
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Additional Information: | This is the peer reviewed version of the following article: Georgi F, Greber UF. The Adenovirus Death Protein - A small membrane protein controls cell lysis and disease [published online ahead of print, 2020 May 30]. FEBS Lett. 2020;10.1002/1873-3468.13848, which has been published in final form at https://doi.org/10.1002/1873-3468.13848 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
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OA Status: | Hybrid |
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Free access at: | Publisher DOI. An embargo period may apply. |
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Publisher DOI: | https://doi.org/10.1002/1873-3468.13848 |
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PubMed ID: | 32472693 |
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