Header

UZH-Logo

Maintenance Infos

IntelliCage as a tool for measuring mouse behavior – 20 years perspective


Kiryk, Anna; Janusz, Artur; Zglinicki, Bartosz; Turkes, Emir; Knapska, Ewelina; Konopka, Witold; Lipp, Hans-Peter; Kaczmarek, Leszek (2020). IntelliCage as a tool for measuring mouse behavior – 20 years perspective. Behavioural Brain Research, 388:112620.

Abstract

Since the 1980s, we have witnessed the rapid development of genetically modified mouse models of human diseases. A large number of transgenic and knockout mice have been utilized in basic and applied research, including models of neurodegenerative and neuropsychiatric disorders. To assess the biological function of mutated genes, modern techniques are critical to detect changes in behavioral phenotypes. We review the IntelliCage, a high-throughput system that is used for behavioral screening and detailed analyses of complex behaviors in mice. The IntelliCage was introduced almost two decades ago and has been used in over 150 studies to assess both spontaneous and cognitive behaviors. We present a critical analysis of experimental data that have been generated using this device.

Abstract

Since the 1980s, we have witnessed the rapid development of genetically modified mouse models of human diseases. A large number of transgenic and knockout mice have been utilized in basic and applied research, including models of neurodegenerative and neuropsychiatric disorders. To assess the biological function of mutated genes, modern techniques are critical to detect changes in behavioral phenotypes. We review the IntelliCage, a high-throughput system that is used for behavioral screening and detailed analyses of complex behaviors in mice. The IntelliCage was introduced almost two decades ago and has been used in over 150 studies to assess both spontaneous and cognitive behaviors. We present a critical analysis of experimental data that have been generated using this device.

Statistics

Citations

Altmetrics

Downloads

17 downloads since deposited on 23 Jun 2020
17 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
04 Faculty of Medicine > Institute of Evolutionary Medicine
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Behavioral Neuroscience
Uncontrolled Keywords:Behavioral Neuroscience
Language:English
Date:1 June 2020
Deposited On:23 Jun 2020 09:20
Last Modified:29 Jul 2020 15:19
Publisher:Elsevier
ISSN:0166-4328
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.bbr.2020.112620
PubMed ID:32302617

Download

Hybrid Open Access

Download PDF  'IntelliCage as a tool for measuring mouse behavior – 20 years perspective'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 7MB
View at publisher
Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)