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Getting back on track: exploiting canalization to uncover the mechanisms of developmental robustness


Wong, Mie; Gilmour, Darren (2020). Getting back on track: exploiting canalization to uncover the mechanisms of developmental robustness. Current Opinion in Genetics & Development, 63:53-60.

Abstract

Developing embryos can adapt dynamically to noise and variation to generate organs of incredible precision, a process termed ‘canalization’; however, the underlying robustness mechanisms are poorly understood. Technological developments, both in quantitative imaging and high precision perturbation, are now enabling targeted investigation into developmental robustness in vivo. Here, we will first distil the common design features of studies that have exploited the canalization behaviour of specific systems to interrogate developmental adaptation, to provide a general experimental framework for future investigations in other contexts. We will then highlight, using a selection of recent case studies, how this approach is revealing that tissues and embryos can fix themselves in unexpected ways.

Abstract

Developing embryos can adapt dynamically to noise and variation to generate organs of incredible precision, a process termed ‘canalization’; however, the underlying robustness mechanisms are poorly understood. Technological developments, both in quantitative imaging and high precision perturbation, are now enabling targeted investigation into developmental robustness in vivo. Here, we will first distil the common design features of studies that have exploited the canalization behaviour of specific systems to interrogate developmental adaptation, to provide a general experimental framework for future investigations in other contexts. We will then highlight, using a selection of recent case studies, how this approach is revealing that tissues and embryos can fix themselves in unexpected ways.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Genetics
Life Sciences > Developmental Biology
Uncontrolled Keywords:Developmental Biology, Genetics
Language:English
Date:1 May 2020
Deposited On:29 Jun 2020 15:06
Last Modified:03 Jul 2020 03:36
Publisher:Elsevier
ISSN:0959-437X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.gde.2020.04.001
PubMed ID:32422503
Project Information:
  • : FunderSNSF
  • : Grant ID31003A_176235
  • : Project TitleCellular mechanisms of organ self-assembly in vivo

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