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Towing of sensory axons by their migrating target cells in vivo


Gilmour, Darren; Knaut, Holger; Maischein, Hans-Martin; Nüsslein-Volhard, Christiane (2004). Towing of sensory axons by their migrating target cells in vivo. Nature Neuroscience, 7(5):491-492.

Abstract

Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.

Abstract

Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:May 2004
Deposited On:03 Jul 2020 03:20
Last Modified:31 Jul 2020 03:53
Publisher:Nature Publishing Group
ISSN:1097-6256
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/nn1235
PubMed ID:15097993

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