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Dysbiosis is not present in horses with fecal water syndrome when compared to controls in spring and autumn


Schoster, Angelika; Weese, J Scott; Gerber, Vinzenz; Nicole Graubner, Claudia (2020). Dysbiosis is not present in horses with fecal water syndrome when compared to controls in spring and autumn. Journal of Veterinary Internal Medicine, 34(4):1614-1621.

Abstract

Background: Fecal water syndrome (FWS) is long‐standing and common in horses, particularly in central Europe. No large epidemiological data sets exist, and the cause remains elusive. Dysbiosis could play a role in pathogenesis.
Objectives: To evaluate whether dysbiosis is present in horses with FWS when compared to stable‐matched control horses in spring and autumn.
Animals: Fecal samples were collected from horses with FWS (n = 16; 9 mares, 7 geldings) and controls (n = 15; 8 mares, 7 geldings).
Methods: The bacterial microbiome of samples collected in spring and autumn of 2016 was analyzed using high‐throughput sequencing. Differences in relative abundance of bacterial taxa, alpha diversity, and beta diversity indices were assessed between horses with FWS and controls based on season.
Results: Differences in microbial community composition based on time point and health status were not observed on any taxonomic level. Limited differences were seen on linear discriminant analysis effect size analysis. No difference in alpha diversity indices was observed including richness, diversity based on health status, or time point. No effect of health status on microbial community membership structure was observed.
Conclusions and Clinical Importance: Limited differences were found in the bacterial microbiota of horses with and without FWS, regardless of season. Further research is needed to elucidate the role of microbiota in the development of FWS.

Abstract

Background: Fecal water syndrome (FWS) is long‐standing and common in horses, particularly in central Europe. No large epidemiological data sets exist, and the cause remains elusive. Dysbiosis could play a role in pathogenesis.
Objectives: To evaluate whether dysbiosis is present in horses with FWS when compared to stable‐matched control horses in spring and autumn.
Animals: Fecal samples were collected from horses with FWS (n = 16; 9 mares, 7 geldings) and controls (n = 15; 8 mares, 7 geldings).
Methods: The bacterial microbiome of samples collected in spring and autumn of 2016 was analyzed using high‐throughput sequencing. Differences in relative abundance of bacterial taxa, alpha diversity, and beta diversity indices were assessed between horses with FWS and controls based on season.
Results: Differences in microbial community composition based on time point and health status were not observed on any taxonomic level. Limited differences were seen on linear discriminant analysis effect size analysis. No difference in alpha diversity indices was observed including richness, diversity based on health status, or time point. No effect of health status on microbial community membership structure was observed.
Conclusions and Clinical Importance: Limited differences were found in the bacterial microbiota of horses with and without FWS, regardless of season. Further research is needed to elucidate the role of microbiota in the development of FWS.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:General Veterinary
Language:English
Date:1 July 2020
Deposited On:03 Jul 2020 16:50
Last Modified:25 Jul 2020 01:07
Publisher:Wiley Open Access
ISSN:0891-6640
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jvim.15778

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