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Are Nestin-positive cells responsive to stress?


Bornstein, Stefan R; Berger, Ilona; Steenblock, Charlotte (2020). Are Nestin-positive cells responsive to stress? Stress, 23(6):662-666.

Abstract

In a number of adult tissues, Nestin-positive stem cells/progenitors have been identified and shown to be involved in maintenance and remodeling. Various studies have shown that under stressful conditions, quiescent Nestin-positive progenitor cells are activated. Thereby, they migrate to their target location and differentiate into mature cells. In the current paper, we discuss if Nestin-positive progenitors in the hippocampus and adrenal gland belong to unique cell populations that are responsive to stress. Furthermore, we speculate about the mechanism behind their activation and the clinical importance of this stress-response.

Abstract

In a number of adult tissues, Nestin-positive stem cells/progenitors have been identified and shown to be involved in maintenance and remodeling. Various studies have shown that under stressful conditions, quiescent Nestin-positive progenitor cells are activated. Thereby, they migrate to their target location and differentiate into mature cells. In the current paper, we discuss if Nestin-positive progenitors in the hippocampus and adrenal gland belong to unique cell populations that are responsive to stress. Furthermore, we speculate about the mechanism behind their activation and the clinical importance of this stress-response.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Social Sciences & Humanities > Neuropsychology and Physiological Psychology
Life Sciences > Endocrine and Autonomic Systems
Health Sciences > Psychiatry and Mental Health
Life Sciences > Behavioral Neuroscience
Language:English
Date:1 November 2020
Deposited On:24 Nov 2020 15:35
Last Modified:31 Dec 2020 02:03
Publisher:Taylor & Francis
ISSN:1025-3890
OA Status:Closed
Publisher DOI:https://doi.org/10.1080/10253890.2020.1766441
PubMed ID:32393094

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