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Fatty acids of microbial origin in the perirenal fat of rats (Rattus norvegicus domestica) and guinea pigs (Cavia porcellus) fed various diets


De Cuyper, Annelies; Winkler, Daniela; Tütken, Thomas; Janssens, Geert P J; Clauss, Marcus (2020). Fatty acids of microbial origin in the perirenal fat of rats (Rattus norvegicus domestica) and guinea pigs (Cavia porcellus) fed various diets. Lipids, 55(4):341-351.

Abstract

Guinea pigs are assumed to practice caecotrophy to a higher degree than rats. Studies from leporids suggest that through the practice of caecotrophy, hindgut fermenting species could build up microbial fatty acids (FA) in body tissues. We hypothesized that microbial FA would be detectable in the body tissue of guinea pigs and rats, and this to a higher degree in guinea pigs. Twenty-four rats and guinea pigs were fed with four different pelleted diets (lucerne-, meat-, meat-bone-, insect-based) in groups of six animals for 8 weeks. Perirenal adipose tissue differed in FA composition between the species in spite of the common diets. FA typically associated with microbial activity (saturated FA (SFA; typically 18:0), monounsaturated FA (MUFA; typically trans-fatty acids TFA), and odd- and branched-chain FA (Iso-FA)), were all detected. Guinea pigs had higher SFA levels than rats except on the lucerne diet. Concentrations of 18:0 were higher for guinea pigs on the meat and bone diet. Iso-FA concentrations in guinea pigs exceeded those of rats on all diets. FA profiles with a microbial fingerprint appear—although in low proportions—in the body tissue of both species, and this seemingly to a higher extent in guinea pigs. With respect to whether consumption of rodent meat rich in microbial FA has particular effects on human health as shown for ruminant products, microbial FA concentrations are probably too low to cause any distinct effects.

Abstract

Guinea pigs are assumed to practice caecotrophy to a higher degree than rats. Studies from leporids suggest that through the practice of caecotrophy, hindgut fermenting species could build up microbial fatty acids (FA) in body tissues. We hypothesized that microbial FA would be detectable in the body tissue of guinea pigs and rats, and this to a higher degree in guinea pigs. Twenty-four rats and guinea pigs were fed with four different pelleted diets (lucerne-, meat-, meat-bone-, insect-based) in groups of six animals for 8 weeks. Perirenal adipose tissue differed in FA composition between the species in spite of the common diets. FA typically associated with microbial activity (saturated FA (SFA; typically 18:0), monounsaturated FA (MUFA; typically trans-fatty acids TFA), and odd- and branched-chain FA (Iso-FA)), were all detected. Guinea pigs had higher SFA levels than rats except on the lucerne diet. Concentrations of 18:0 were higher for guinea pigs on the meat and bone diet. Iso-FA concentrations in guinea pigs exceeded those of rats on all diets. FA profiles with a microbial fingerprint appear—although in low proportions—in the body tissue of both species, and this seemingly to a higher extent in guinea pigs. With respect to whether consumption of rodent meat rich in microbial FA has particular effects on human health as shown for ruminant products, microbial FA concentrations are probably too low to cause any distinct effects.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Life Sciences > Biochemistry
Physical Sciences > Organic Chemistry
Life Sciences > Cell Biology
Uncontrolled Keywords:Organic Chemistry, Cell Biology, Biochemistry, Caecotrophy; Guinea pig; Iso-FA; Microbial fatty acids; Perirenal fat; Rat.
Language:English
Date:1 July 2020
Deposited On:13 Jul 2020 14:48
Last Modified:29 Jul 2020 15:26
Publisher:Springer
ISSN:0024-4201
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/lipd.12240
PubMed ID:32343435
Project Information:
  • : FunderH2020
  • : Grant ID681450
  • : Project TitleVERTEBRATE HERBIVORY - Evolution of herbivory in vertebrates: developing combined isotope (Ca, Sr) and dental surface texture analysis as deep time diet proxies

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