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Anti-dopamine D2 receptor antibodies in chronic tic disorders


Addabbo, Francesco; Baglioni, Valentina; Schrag, Anette; Schwarz, Markus J; Dietrich, Andrea; Hoekstra, Pieter J; Martino, Davide; Buttiglione, Maura; Emtics Collaborative Group; et al; Ball, Juliane; Tagwerker Gloor, Friederike; Walitza, Susanne (2020). Anti-dopamine D2 receptor antibodies in chronic tic disorders. Developmental Medicine and Child Neurology, 62(10):1205-1212.

Abstract

AIM To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).

METHOD

One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.

RESULTS

At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.

INTERPRETATION There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

Abstract

AIM To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).

METHOD

One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.

RESULTS

At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.

INTERPRETATION There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 October 2020
Deposited On:14 Jul 2020 05:28
Last Modified:04 Sep 2020 01:06
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0012-1622
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/dmcn.14613
PubMed ID:32644201
Project Information:
  • : FunderFP7
  • : Grant ID278367
  • : Project TitleEuropean Multicentre Tics in Children Studies

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