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Dual Photoredox/Nickel‐Catalyzed Three‐Component Carbofunctionalization of Alkenes


García‐Domínguez, Andrés; Mondal, Rahul; Nevado, Cristina (2019). Dual Photoredox/Nickel‐Catalyzed Three‐Component Carbofunctionalization of Alkenes. Angewandte Chemie Internationale Edition, 58(35):12286-12290.

Abstract

The potential of merging photoredox and nickel catalysis to perform multicomponent alkene difunctionalizations under visible‐light irradiation is demonstrated here. Secondary and tertiary alkyl groups, as well as sulfonyl moieties can be added to the terminal position of the double bond with simultaneous arylation of the internal carbon atom in a single step under mild reaction conditions. The process, devoid of stoichiometric additives, benefits from the use of bench‐stable and easy‐to‐handle reagents, is operationally simple, and tolerates a wide variety of functional groups.

Abstract

The potential of merging photoredox and nickel catalysis to perform multicomponent alkene difunctionalizations under visible‐light irradiation is demonstrated here. Secondary and tertiary alkyl groups, as well as sulfonyl moieties can be added to the terminal position of the double bond with simultaneous arylation of the internal carbon atom in a single step under mild reaction conditions. The process, devoid of stoichiometric additives, benefits from the use of bench‐stable and easy‐to‐handle reagents, is operationally simple, and tolerates a wide variety of functional groups.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Catalysis
Physical Sciences > General Chemistry
Uncontrolled Keywords:General Chemistry, Catalysis
Language:English
Date:26 August 2019
Deposited On:29 Jul 2020 08:51
Last Modified:23 Jun 2024 01:41
Publisher:Wiley-VCH Verlag
ISSN:1433-7851
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/anie.201906692
Project Information:
  • : FunderFP7
  • : Grant ID307948
  • : Project TitleNIGOCAT - Nature-Inspired Gold Catalytic Tools
  • : FunderSNSF
  • : Grant ID200020_146853
  • : Project TitleNovel Synthetic Methods based on Gold Catalyzed Reactions
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