We analyse the sensitivity of quark flavour-changing observables to the MSSM, in a regime of heavy superpartners. We analyse four distinct and motivated frameworks characterising the structure of the soft-breaking terms by means of approximate flavour symmetries. We show that a set of six low-energy observables with realistic chances of improvement in the near future, namely ΔMs,d, ϵK, ϵ′K/ϵK, B(K→πνν¯), and the phase of D–D¯ mixing, could play a very important role in characterising these frameworks for superpartner masses up to O(100) TeV. We show that these observables remain very interesting even in a long-term perspective, i.e. even taking into account the direct mass reach of the most ambitious future high-energy colliders.