In this paper, we present results at next-to-leading order (NLO) QCD for photon pair production in association with two jets via vector boson scattering within the Standard Model (SM), and also in an effective field theory framework with anomalous gauge coupling effects via bosonic dimension-6 and 8 operators. We observe that, compared to other processes in the class of two electroweak (EW) vector boson production in association with two jets, more exclusive cuts are needed in order to suppress the SM QCD-induced background channel. As expected, the NLO QCD corrections reduce the scale uncertainties considerably. Using a well-motivated dynamical scale choice, we find moderate K -factors for the EW-induced process while the QCD-induced channel receives much larger corrections. Furthermore, we observe that applying a cut of Δϕcutj2γ1<2.5 for the second hardest jet and the hardest photon helps to increase the signal significance and reduces the impact of higher-order QCD corrections.