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Occupational exposure and the risk of airway obstruction and mortality


Strassmann, Alexandra; Kaufmann, Marco; Dressel, Holger; Turk, Alexander; Röösli, Martin; de Hoogh, Kees; Sadhra, Steven S; Bopp, Matthias; Puhan, Milo A (2020). Occupational exposure and the risk of airway obstruction and mortality. International Journal of Public Health, 65(6):823-833.

Abstract

Objectives: To identify occupational groups at high risk of airway obstruction (AO) and mortality and potential interactions with smoking.
Methods: Lung function data from the LuftiBus project were enriched with occupational and follow-up information from the Swiss National Cohort, resulting in a cohort of 10582 adults between 2000 and 2015. We assigned professions to occupational groups and estimated the risk of AO and mortality using adjusted logistic and Cox regression model. Additionally, we assessed multiplicative and additive interactions between occupational exposure and smoking.
Results: Chimney sweeps and male workers from the agriculture, construction and food industries had an increased risk of AO (odds ratios ranging from 1.43 to 2.21). The risk of mortality was increased among male workers from the food industry (hazard ratio 1.57, 95% CI 1.10-2.23). Interactions with smoking were present in most associations, but smoking had no effect on the increased risk of mortality in the food industry.
Conclusions: Some occupational groups have a considerable risk of AO and mortality. The identification of the most affected occupations is of great importance enabling targeted risk reduction strategies.

Abstract

Objectives: To identify occupational groups at high risk of airway obstruction (AO) and mortality and potential interactions with smoking.
Methods: Lung function data from the LuftiBus project were enriched with occupational and follow-up information from the Swiss National Cohort, resulting in a cohort of 10582 adults between 2000 and 2015. We assigned professions to occupational groups and estimated the risk of AO and mortality using adjusted logistic and Cox regression model. Additionally, we assessed multiplicative and additive interactions between occupational exposure and smoking.
Results: Chimney sweeps and male workers from the agriculture, construction and food industries had an increased risk of AO (odds ratios ranging from 1.43 to 2.21). The risk of mortality was increased among male workers from the food industry (hazard ratio 1.57, 95% CI 1.10-2.23). Interactions with smoking were present in most associations, but smoking had no effect on the increased risk of mortality in the food industry.
Conclusions: Some occupational groups have a considerable risk of AO and mortality. The identification of the most affected occupations is of great importance enabling targeted risk reduction strategies.

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Additional indexing

Contributors:Swiss National Cohort Study Group
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Public Health, Environmental and Occupational Health
Uncontrolled Keywords:Public Health, Environmental and Occupational Health, Health(social science), Airway obstruction; Industries; Interaction; Mortality; Occupational exposure.
Language:English
Date:1 July 2020
Deposited On:14 Aug 2020 14:34
Last Modified:15 Aug 2020 20:00
Publisher:Springer
ISSN:1661-8556
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00038-020-01400-8
PubMed ID:32529533
Project Information:
  • : FunderSNSF
  • : Grant ID32473B_173043
  • : Project TitleInvestigating the interplay of job exposures, ambient air pollution and living environment as drivers of the chronic lung disease epidemic The Large-scale LuftiBus-SNC Cohort

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