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Hypoxia‐induced pulmonary hypertension – utilising experiments of nature

Gassmann, Max; Cowburn, Andrew; Gu, Hong; Li, Jia; Rodriguez, Marisela; Babicheva, Aleksandra; Jain, Pritesh P; Xiong, Mingmei; Gassmann, Norina N; Yuan, Jason X‐J; Wilkins, Martin R; Zhao, Lan (2021). Hypoxia‐induced pulmonary hypertension – utilising experiments of nature. British Journal of Pharmacology, 178(1):121-131.

Abstract

An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest to understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature; specifically, to understand the genetic basis for the inter-individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather that cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Zurich Center for Integrative Human Physiology (ZIHP)
05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Pharmacology
Uncontrolled Keywords:Pharmacology, High-altitude; genetics; hypoxia-inducible factor; oxygen sensing, hypoxia-inducible factor prolyl hydroxylase 2, pulmonary vasoconstriction; vascular remodelling.
Language:English
Date:1 January 2021
Deposited On:27 Aug 2020 14:38
Last Modified:23 Oct 2024 01:40
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0007-1188
Additional Information:This is the peer reviewed version of the following article: Gassmann M, Cowburn A, Gu H, et al. Hypoxia-induced pulmonary hypertension - utilising experiments of nature [published online ahead of print, 2020 May 28]. Br J Pharmacol. 2020, which has been published in final form at https://doi.org/10.1111/bph.15144. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/bph.15144
PubMed ID:32464698
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