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Randomized controlled trial of pregabalin for analgesia after surgical treatment of intervertebral disc disease in dogs


Schmierer, Philipp A; Tünsmeyer, Julia; Tipold, Andrea; Hartnack-Wilhelm, Sonja; Lesczuk, Piotr; Kästner, Sabine Beate Rita (2020). Randomized controlled trial of pregabalin for analgesia after surgical treatment of intervertebral disc disease in dogs. Veterinary Surgery, 49(5):905-913.

Abstract

Methods: Dogs were randomly assigned to two groups, with the placebo group receiving opioids alone and the pregabalin group receiving opioids plus pregabalin. Opioid analgesia consisted of 0.6 mg/kg l‐methadone given intravenously at anesthetic induction, followed by 0.2 mg/kg given at 8, 16, and 24 hours after extubation and fentanyl patches applied at the end of surgery. Pregabalin was given orally (4 mg/kg) 1 hour before anesthesia, followed by postoperative treatment three times per day (4 mg/kg) for 5 days. The outcome measures were the treatment‐group differences in peri‐incisional mechanical sensitivity and Glasgow Composite Measure Pain Scale (CMPS‐SF) assessed during the first 5 postoperative days. Pregabalin serum concentrations were measured after 24, 72, and 120 hours.
Results: Pregabalin reduced pain levels in the treatment group by a mean of 2.5 CMPS‐SF units (95% confidence interval [CI] = −3.19 to −1.83, P < .001) compared with the control group during the study period. Pregabalin increased the mechanical nociceptive threshold by a mean of 6.89 N per day (95% CI = 1.87‐11.92, P < .001) and of 7.52 N per day (95% CI = 2.29‐12.77, P < .001) during the study period, depending on location. Mean levels of serum pregabalin were 5.1, 4.71, and 3.68 μg/mL at 24, 72, and 120 hours postoperatively, respectively.
Conclusion: Postoperative signs of pain after surgical treatment of intervertebral disc herniation (IVDH) were reduced when dogs received perioperative pregabalin rather than opioids alone.
Clinical significance: Perioperative pregabalin reduces postoperative pain after surgical treatment of IVDH.

Abstract

Methods: Dogs were randomly assigned to two groups, with the placebo group receiving opioids alone and the pregabalin group receiving opioids plus pregabalin. Opioid analgesia consisted of 0.6 mg/kg l‐methadone given intravenously at anesthetic induction, followed by 0.2 mg/kg given at 8, 16, and 24 hours after extubation and fentanyl patches applied at the end of surgery. Pregabalin was given orally (4 mg/kg) 1 hour before anesthesia, followed by postoperative treatment three times per day (4 mg/kg) for 5 days. The outcome measures were the treatment‐group differences in peri‐incisional mechanical sensitivity and Glasgow Composite Measure Pain Scale (CMPS‐SF) assessed during the first 5 postoperative days. Pregabalin serum concentrations were measured after 24, 72, and 120 hours.
Results: Pregabalin reduced pain levels in the treatment group by a mean of 2.5 CMPS‐SF units (95% confidence interval [CI] = −3.19 to −1.83, P < .001) compared with the control group during the study period. Pregabalin increased the mechanical nociceptive threshold by a mean of 6.89 N per day (95% CI = 1.87‐11.92, P < .001) and of 7.52 N per day (95% CI = 2.29‐12.77, P < .001) during the study period, depending on location. Mean levels of serum pregabalin were 5.1, 4.71, and 3.68 μg/mL at 24, 72, and 120 hours postoperatively, respectively.
Conclusion: Postoperative signs of pain after surgical treatment of intervertebral disc herniation (IVDH) were reduced when dogs received perioperative pregabalin rather than opioids alone.
Clinical significance: Perioperative pregabalin reduces postoperative pain after surgical treatment of IVDH.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
05 Vetsuisse Faculty > Chair in Veterinary Epidemiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > General Veterinary
Uncontrolled Keywords:General Veterinary
Language:English
Date:1 July 2020
Deposited On:02 Sep 2020 19:04
Last Modified:06 Sep 2020 12:10
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0161-3499
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/vsu.13411
PubMed ID:32329092
Project Information:
  • : FunderDie Gesellschaft zur Förderung Kynologischer Forschung e.V.
  • : Grant ID
  • : Project Title

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