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Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc‐1α expression: Follow‐up to an in vitro magnetic mitohormetic study


Abstract

Exercise modulates metabolism and the gut microbiome. Brief exposure to low mT‐range pulsing electromagnetic fields (PEMFs) was previously shown to accentuate in vitro myogenesis and mitochondriogenesis by activating a calcium‐mitochondrial axis upstream of PGC‐1α transcriptional upregulation, recapitulating a genetic response implicated in exercise‐induced metabolic adaptations. We compared the effects of analogous PEMF exposure (1.5 mT, 10 min/week), with and without exercise, on systemic metabolism and gut microbiome in four groups of mice: (a) no intervention; (b) PEMF treatment; (c) exercise; (d) exercise and PEMF treatment. The combination of PEMFs and exercise for 6 weeks enhanced running performance and upregulated muscular and adipose Pgc‐1α transcript levels, whereas exercise alone was incapable of elevating Pgc‐1α levels. The gut microbiome Firmicutes/Bacteroidetes ratio decreased with exercise and PEMF exposure, alone or in combination, which has been associated in published studies with an increase in lean body mass. After 2 months, brief PEMF treatment alone increased Pgc‐1α and mitohormetic gene expression and after >4 months PEMF treatment alone enhanced oxidative muscle expression, fatty acid oxidation, and reduced insulin levels. Hence, short‐term PEMF treatment was sufficient to instigate PGC‐1α‐associated transcriptional cascades governing systemic mitohormetic adaptations, whereas longer‐term PEMF treatment was capable of inducing related metabolic adaptations independently of exercise.

Abstract

Exercise modulates metabolism and the gut microbiome. Brief exposure to low mT‐range pulsing electromagnetic fields (PEMFs) was previously shown to accentuate in vitro myogenesis and mitochondriogenesis by activating a calcium‐mitochondrial axis upstream of PGC‐1α transcriptional upregulation, recapitulating a genetic response implicated in exercise‐induced metabolic adaptations. We compared the effects of analogous PEMF exposure (1.5 mT, 10 min/week), with and without exercise, on systemic metabolism and gut microbiome in four groups of mice: (a) no intervention; (b) PEMF treatment; (c) exercise; (d) exercise and PEMF treatment. The combination of PEMFs and exercise for 6 weeks enhanced running performance and upregulated muscular and adipose Pgc‐1α transcript levels, whereas exercise alone was incapable of elevating Pgc‐1α levels. The gut microbiome Firmicutes/Bacteroidetes ratio decreased with exercise and PEMF exposure, alone or in combination, which has been associated in published studies with an increase in lean body mass. After 2 months, brief PEMF treatment alone increased Pgc‐1α and mitohormetic gene expression and after >4 months PEMF treatment alone enhanced oxidative muscle expression, fatty acid oxidation, and reduced insulin levels. Hence, short‐term PEMF treatment was sufficient to instigate PGC‐1α‐associated transcriptional cascades governing systemic mitohormetic adaptations, whereas longer‐term PEMF treatment was capable of inducing related metabolic adaptations independently of exercise.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Biotechnology
Life Sciences > Biochemistry
Life Sciences > Molecular Biology
Life Sciences > Genetics
Uncontrolled Keywords:Biotechnology, Genetics, Biochemistry, Molecular Biology
Language:English
Date:1 August 2020
Deposited On:03 Sep 2020 07:57
Last Modified:04 Sep 2020 20:00
Publisher:Federation of American Society of Experimental Biology
ISSN:0892-6638
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1096/fj.201903005rr
PubMed ID:32627872

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