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Ammonium salt-catalyzed ring-opening of aryl-aziridines with β-keto esters


Haider, Victoria; Kreuzer, Viktoria; Tiffner, Maximilian; Spingler, Bernhard; Waser, Mario (2020). Ammonium salt-catalyzed ring-opening of aryl-aziridines with β-keto esters. European Journal of Organic Chemistry, 2020(32):5173-5177.

Abstract

We herein report an ammonium salt-catalyzed protocol for the regioselective ring opening of aryl-aziridines with beta-keto esters. The reaction gives access to a variety of highly functionalized target molecules with two consecutive stereogenic
centers and can be rendered enantioselective (up to e.r. = 91:9) by using bifunctional chiral ammonium salt catalysts.

Abstract

We herein report an ammonium salt-catalyzed protocol for the regioselective ring opening of aryl-aziridines with beta-keto esters. The reaction gives access to a variety of highly functionalized target molecules with two consecutive stereogenic
centers and can be rendered enantioselective (up to e.r. = 91:9) by using bifunctional chiral ammonium salt catalysts.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Organic Chemistry
Uncontrolled Keywords:Physical and Theoretical Chemistry, Organic Chemistry
Language:English
Date:10 August 2020
Deposited On:07 Sep 2020 16:04
Last Modified:09 Sep 2020 16:33
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1099-0690
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1002/ejoc.202000916

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