Header

UZH-Logo

Maintenance Infos

Echocardiographic predictors of first onset of atrial fibrillation in dogs with myxomatous mitral valve disease


Baron Toaldo, Marco; Mazzoldi, Chiara; Romito, Giovanni; Poser, Helen; Contiero, Barbara; Cipone, Mario; Guglielmini, Carlo (2020). Echocardiographic predictors of first onset of atrial fibrillation in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine:Epub ahead of print.

Abstract

Background
Atrial fibrillation (AF) occurs in dogs with myxomatous mitral valve disease (MMVD) as a consequence of left atrial (LA) dilatation, and it affects survival and quality of life.
Objectives
To evaluate the usefulness of echocardiography in predicting the first occurrence of AF in dogs with MMVD.
Animals
Forty‐four client‐owned dogs with MMVD, 22 dogs that developed AF, and 22 dogs that maintained sinus rhythm.
Methods
Retrospective observational study. Medical databases were reviewed for dogs that developed AF during the year after diagnosis of MMVD (AF group). The last echocardiographic examination obtained while still in sinus rhythm was used to derive selected variables. For each dog with AF, a control dog matched for body weight, class of heart failure, and LA dimension was selected. Echocardiographic results including LA volumes and LA speckle tracking echocardiography (STE)‐derived variables were measured.
Results
Among the tested echocardiographic variables, only LA diameter (P = .03) and left ventricular internal diameter in diastole (P = .03) differed significantly between groups, whereas body weight‐indexed variables of cardiac dimension as well as LA volumes and volume‐derived functional variables were not different. Among the STE‐derived variables, peak atrial longitudinal strain (PALS) results differed significantly between the AF group (23.8% ± 8.6%) and the control group (30.5% ± 9.6%; P = .03). A value of PALS ≤28% predicted AF occurrence with sensitivity and specificity of 0.80 and 0.65, respectively.
Conclusions and Clinical Importance
Absolute cardiac diameters and LA STE (in particular, PALS) are useful echocardiographic predictors for the development of AF in dogs with MMVD.

Abstract

Background
Atrial fibrillation (AF) occurs in dogs with myxomatous mitral valve disease (MMVD) as a consequence of left atrial (LA) dilatation, and it affects survival and quality of life.
Objectives
To evaluate the usefulness of echocardiography in predicting the first occurrence of AF in dogs with MMVD.
Animals
Forty‐four client‐owned dogs with MMVD, 22 dogs that developed AF, and 22 dogs that maintained sinus rhythm.
Methods
Retrospective observational study. Medical databases were reviewed for dogs that developed AF during the year after diagnosis of MMVD (AF group). The last echocardiographic examination obtained while still in sinus rhythm was used to derive selected variables. For each dog with AF, a control dog matched for body weight, class of heart failure, and LA dimension was selected. Echocardiographic results including LA volumes and LA speckle tracking echocardiography (STE)‐derived variables were measured.
Results
Among the tested echocardiographic variables, only LA diameter (P = .03) and left ventricular internal diameter in diastole (P = .03) differed significantly between groups, whereas body weight‐indexed variables of cardiac dimension as well as LA volumes and volume‐derived functional variables were not different. Among the STE‐derived variables, peak atrial longitudinal strain (PALS) results differed significantly between the AF group (23.8% ± 8.6%) and the control group (30.5% ± 9.6%; P = .03). A value of PALS ≤28% predicted AF occurrence with sensitivity and specificity of 0.80 and 0.65, respectively.
Conclusions and Clinical Importance
Absolute cardiac diameters and LA STE (in particular, PALS) are useful echocardiographic predictors for the development of AF in dogs with MMVD.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

0 downloads since deposited on 15 Sep 2020
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Health Sciences > General Veterinary
Uncontrolled Keywords:General Veterinary
Language:English
Date:7 August 2020
Deposited On:15 Sep 2020 16:09
Last Modified:16 Sep 2020 20:00
Publisher:Wiley Open Access
ISSN:0891-6640
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jvim.15860

Download

Gold Open Access

Download PDF  'Echocardiographic predictors of first onset of atrial fibrillation in dogs with myxomatous mitral valve disease'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)