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Intrahepatic icterus in pigs: rare clinical sign in porcine circovirus type 2 systemic disease


Graage, Robert; Saura Martinez, Helena; Klausmann, Stefanie; Kubacki, Jakub; Kümmerlen, Dolf (2020). Intrahepatic icterus in pigs: rare clinical sign in porcine circovirus type 2 systemic disease. Veterinary Record Case Reports, 8(3):e001193.

Abstract

Icterus is a yellow discolouration of tissue and blood plasma due to a disorder of the bilirubin metabolism. This case report describes two porcine circovirus type 2 (PCV2) outbreaks in a fattening farm (F1) and a breeding farm (F2). At F1, pigs had intradermal bleedings and wasting, and three pigs showed icterus. At F2, suckling and weaning pigs (WPs) had an icterus and were wasted. Three fattening pigs (F1), one suckling piglet and one WP (F2) were dissected. Additional investigations included histology, PCV2 immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH) of tissue samples, PCR including sequencing of the PCV2 strains and next-generation sequencing (NGS) of liver samples. Three of the five dissected pigs showed a lymphohistiocytic, periportal hepatitis with disruption of the hepatic cord architecture. PCV2 was detected by IHC, FISH, PCR and NGS in several organs of the pigs. In both farms, sequencing revealed a PCV2b genotype.

Abstract

Icterus is a yellow discolouration of tissue and blood plasma due to a disorder of the bilirubin metabolism. This case report describes two porcine circovirus type 2 (PCV2) outbreaks in a fattening farm (F1) and a breeding farm (F2). At F1, pigs had intradermal bleedings and wasting, and three pigs showed icterus. At F2, suckling and weaning pigs (WPs) had an icterus and were wasted. Three fattening pigs (F1), one suckling piglet and one WP (F2) were dissected. Additional investigations included histology, PCV2 immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH) of tissue samples, PCR including sequencing of the PCV2 strains and next-generation sequencing (NGS) of liver samples. Three of the five dissected pigs showed a lymphohistiocytic, periportal hepatitis with disruption of the hepatic cord architecture. PCV2 was detected by IHC, FISH, PCR and NGS in several organs of the pigs. In both farms, sequencing revealed a PCV2b genotype.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Health Sciences > General Veterinary
Uncontrolled Keywords:General Veterinary
Language:English
Date:1 August 2020
Deposited On:20 Oct 2020 16:32
Last Modified:20 Oct 2020 16:39
Publisher:British Veterinary Association
ISSN:2052-6121
OA Status:Closed
Publisher DOI:https://doi.org/10.1136/vetreccr-2020-001193

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