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On probing intravoxel incoherent motion in the heart‐spin‐echo versus stimulated‐echo DWI


Spinner, Georg R; Stoeck, Christian T; Mathez, Linda; von Deuster, Constantin; Federau, Christian; Kozerke, Sebastian (2019). On probing intravoxel incoherent motion in the heart‐spin‐echo versus stimulated‐echo DWI. Magnetic Resonance in Medicine, 82(3):1150-1163.

Abstract

Purpose: Mapping intravoxel incoherent motion (IVIM) in the heart remains challenging despite advances in cardiac DWI and DTI. In the present work, simulations and experimental imaging are used to compare the IVIM encoding efficiency of spin-echo- and stimulated-echo-based DWI/DTI for assessing myocardial perfusion.

Methods: Using normalized phase distributions and statistical models of capillary networks derived from histological studies, along with typical diffusion gradient waveforms for in vivo cardiac DWI/DTI, Monte Carlo simulations were performed. The simulation results were compared to IVIM measurements of perfused porcine hearts regarding both magnitude and phase modulation. An IVIM tensor model was used to account for anisotropy of the capillary network, and potential bias of parameter estimation was reported based on simulations.

Results: Both computer simulations and experimental data demonstrate a low sensitivity of spin-echo DWI/DTI sequences for IVIM parameters, whereas stimulated-echo-based DWI/DTI with typical mixing times can differentiate between no-flow baseline and perfused myocardium (+129% IVIM-derived flow). In addition, ischemic territories induced by coronary occlusion could be successfully detected. With increasing order of motion compensation (M0/M1/M2) of the diffusion encoding gradients, as required for cardiac in vivo spin-echo DWI/DTI, the low IVIM sensitivity of spin-echo DWI/DTI decreased further in simulations: maximum attenuations of perfusion compartment 52/13/5% (b = 500 s/mm2 ).

Conclusion: Given the short encoding time of spin-echo-based DWI/DTI sequences, a limited perfusion sensitivity results, in particular in combination with motion-compensated diffusion gradients. In contrast, stimulated-echo based DWI/DTI has the potential to identify perfusion changes in cardiac IVIM in vivo.

Abstract

Purpose: Mapping intravoxel incoherent motion (IVIM) in the heart remains challenging despite advances in cardiac DWI and DTI. In the present work, simulations and experimental imaging are used to compare the IVIM encoding efficiency of spin-echo- and stimulated-echo-based DWI/DTI for assessing myocardial perfusion.

Methods: Using normalized phase distributions and statistical models of capillary networks derived from histological studies, along with typical diffusion gradient waveforms for in vivo cardiac DWI/DTI, Monte Carlo simulations were performed. The simulation results were compared to IVIM measurements of perfused porcine hearts regarding both magnitude and phase modulation. An IVIM tensor model was used to account for anisotropy of the capillary network, and potential bias of parameter estimation was reported based on simulations.

Results: Both computer simulations and experimental data demonstrate a low sensitivity of spin-echo DWI/DTI sequences for IVIM parameters, whereas stimulated-echo-based DWI/DTI with typical mixing times can differentiate between no-flow baseline and perfused myocardium (+129% IVIM-derived flow). In addition, ischemic territories induced by coronary occlusion could be successfully detected. With increasing order of motion compensation (M0/M1/M2) of the diffusion encoding gradients, as required for cardiac in vivo spin-echo DWI/DTI, the low IVIM sensitivity of spin-echo DWI/DTI decreased further in simulations: maximum attenuations of perfusion compartment 52/13/5% (b = 500 s/mm2 ).

Conclusion: Given the short encoding time of spin-echo-based DWI/DTI sequences, a limited perfusion sensitivity results, in particular in combination with motion-compensated diffusion gradients. In contrast, stimulated-echo based DWI/DTI has the potential to identify perfusion changes in cardiac IVIM in vivo.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Scopus Subject Areas:Health Sciences > Radiology, Nuclear Medicine and Imaging
Language:English
Date:26 April 2019
Deposited On:26 Oct 2020 10:02
Last Modified:27 Oct 2020 21:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0740-3194
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/mrm.27777
PubMed ID:31025435
Project Information:
  • : FunderSNSF
  • : Grant IDPZ00P2_174144
  • : Project TitleMR guided biomechanical modelling of the heart - a novel tool to predict remodelling in heart failure

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