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Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories


Kaufmann, Marco; Salmen, Anke; Barin, Laura; Puhan, Milo A; Calabrese, Pasquale; Kamm, Christian Philipp; Gobbi, Claudio; Kuhle, Jens; Manjaly, Zina-Mary; Ajdacic-Gross, Vladeta; Schafroth, Sandra; Bottignole, Britta; Ammann, Sabin; Zecca, Chiara; D'Souza, Marcus; von Wyl, Viktor (2020). Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories. Multiple Sclerosis and Related Disorders, 42:102148.

Abstract

BACKGROUND: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories.
METHODS: We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity.
RESULTS: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively.
CONCLUSIONS: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.

Abstract

BACKGROUND: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories.
METHODS: We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity.
RESULTS: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively.
CONCLUSIONS: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.

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Additional indexing

Contributors:Swiss Multiple Sclerosis Registry (SMSR)
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Language:English
Date:July 2020
Deposited On:26 Oct 2020 16:42
Last Modified:31 Dec 2020 08:38
Publisher:Elsevier
ISSN:2211-0348
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.msard.2020.102148
PubMed ID:32371376

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