Header

UZH-Logo

Maintenance Infos

T cell immunity to commensal fungi


Scheffold, Alexander; Bacher, Petra; LeibundGut-Landmann, Salomé (2020). T cell immunity to commensal fungi. Current Opinion in Microbiology, 58:116-123.

Abstract

Fungi are an important part of the microbiota in healthy barrier tissues. Fungal dysbiosis in turn is associated with local and distal inflammatory diseases. Recent advances have shed light on the antigen-specific IL-17-dependent mechanisms that regulate fungal commensalism and prevent fungal overgrowth during homeostasis. Progress in our understanding of species-specific differences in fungus-host interactions provides new hypotheses of why Candida albicans-targeting T cells exceed those directed against other fungal species in the human T cell repertoire. Importantly, C. albicans-specific Th17 cells can also contribute to immune pathology in distant organs such as the lung via cross-reaction with heterologous antigens.

Abstract

Fungi are an important part of the microbiota in healthy barrier tissues. Fungal dysbiosis in turn is associated with local and distal inflammatory diseases. Recent advances have shed light on the antigen-specific IL-17-dependent mechanisms that regulate fungal commensalism and prevent fungal overgrowth during homeostasis. Progress in our understanding of species-specific differences in fungus-host interactions provides new hypotheses of why Candida albicans-targeting T cells exceed those directed against other fungal species in the human T cell repertoire. Importantly, C. albicans-specific Th17 cells can also contribute to immune pathology in distant organs such as the lung via cross-reaction with heterologous antigens.

Statistics

Citations

Altmetrics

Downloads

5 downloads since deposited on 02 Nov 2020
5 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Microbiology (medical), Microbiology, Infectious Diseases
Language:English
Date:1 December 2020
Deposited On:02 Nov 2020 16:56
Last Modified:03 Nov 2020 10:43
Publisher:Elsevier
ISSN:1369-5274
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.mib.2020.09.008
Project Information:
  • : FunderSNSF
  • : Grant ID310030_189255
  • : Project TitleFrom commensalism to disease: How skin-resident fungi drive allergic skin disorders
  • : FunderSNSF
  • : Grant ID310030_166206
  • : Project TitleTissue-specific host defense mechanisms against Candida albicans
  • : FunderSNSF
  • : Grant IDCRSII5_173863
  • : Project TitleMultidisciplinary approaches to identify genetic determinants of Candida albicans pathogenicity

Download

Hybrid Open Access

Download PDF  'T cell immunity to commensal fungi'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher
Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)