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Hybrid positron emission tomography imaging for initial staging of sinonasal tumors: Total lesion glycolysis as prognosticator of treatment response


Meerwein, Christian M; Maurer, Alexander; Stolzmann, Paul; Stadler, Thomas M; Soyka, Michael B; Holzmann, David; Hüllner, Martin W (2021). Hybrid positron emission tomography imaging for initial staging of sinonasal tumors: Total lesion glycolysis as prognosticator of treatment response. Head and Neck, 43(1):238-246.

Abstract

Background: To assess hybrid positron emission tomography (PET) imaging in the initial staging and outcome prediction of sinonasal malignancies.
Methods: Retrospective study on patients with sinonasal malignancies undergoing hybrid PET imaging for initial staging.
Results: Complete remission (CR) was achieved in 45 of 65 patients (69.2%). Overall sensitivity for detection of primaries using 18F-fluoro-deoxy-d-glucose PET (FDG-PET) was 95.4%, for lymph node metastases 100% and distant metastases (DM) 100%. On univariate analysis, PET parameter total lesion glycolysis (TLG) was associated with achieving CR after primary treatment (176.8 ± 157.2 vs 83.7 ± 110.8, P = .03). Multivariate logistic regression demonstrated that TLG adjusted for the T classification best predicted achievement of CR.
Conclusions: Hybrid PET imaging yields an excellent sensitivity in detecting primary tumors, lymph node metastases and DM in sinonasal malignancies. TLG of the primary tumor is an independent prognostic factor for achieving CR after initial treatment.

Abstract

Background: To assess hybrid positron emission tomography (PET) imaging in the initial staging and outcome prediction of sinonasal malignancies.
Methods: Retrospective study on patients with sinonasal malignancies undergoing hybrid PET imaging for initial staging.
Results: Complete remission (CR) was achieved in 45 of 65 patients (69.2%). Overall sensitivity for detection of primaries using 18F-fluoro-deoxy-d-glucose PET (FDG-PET) was 95.4%, for lymph node metastases 100% and distant metastases (DM) 100%. On univariate analysis, PET parameter total lesion glycolysis (TLG) was associated with achieving CR after primary treatment (176.8 ± 157.2 vs 83.7 ± 110.8, P = .03). Multivariate logistic regression demonstrated that TLG adjusted for the T classification best predicted achievement of CR.
Conclusions: Hybrid PET imaging yields an excellent sensitivity in detecting primary tumors, lymph node metastases and DM in sinonasal malignancies. TLG of the primary tumor is an independent prognostic factor for achieving CR after initial treatment.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Otorhinolaryngology
Uncontrolled Keywords:Otorhinolaryngology, fluorodeoxyglucose F18; multimodal imaging; otorhinolaryngologic diseases; paranasal sinus neoplasms; positron emission tomography.
Language:English
Date:1 January 2021
Deposited On:05 Nov 2020 15:43
Last Modified:10 Dec 2020 02:31
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1043-3074
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/hed.26476

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