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Aging effects and test-retest reliability of inhibitory control for saccadic eye movements


Płomecka, Martyna Beata; Barańczuk-Turska, Zofia; Pfeiffer, Christian; Langer, Nicolas (2020). Aging effects and test-retest reliability of inhibitory control for saccadic eye movements. eNeuro, 7(5):ENEURO.0459-19.2020.

Abstract

Neuropsychological studies indicate that healthy aging is associated with a decline of inhibitory control of attentional and behavioral systems. A widely accepted measure of inhibitory control is the antisaccade task that requires both the inhibition of a reflexive saccadic response toward a visual target and the initiation of a voluntary eye movement in the opposite direction. To better understand the nature of age-related differences in inhibitory control, we evaluated antisaccade task performance in 78 younger (20-35 years) and 78 older (60-80 years) participants. In order to provide reliable estimates of inhibitory control for individual subjects, we investigated test-retest reliability of the reaction time, error rate, saccadic gain, and peak saccadic velocity and further estimated latent, not directly observable processed contributing to changes in the antisaccade task execution. The intraclass correlation coefficients (ICCs) for an older group of participants emerged as good to excellent for most of our antisaccade task measures. Furthermore, using Bayesian multivariate models, we inspected age-related differences in the performances of healthy younger and older participants. The older group demonstrated higher error rates, longer reaction times, significantly more inhibition failures, and late prosaccades as compared with young adults. The consequently lower ability of older adults to voluntarily inhibit saccadic responses has been interpreted as an indicator of age-related inhibitory control decline. Additionally, we performed a Bayesian model comparison of used computational models and concluded that the Stochastic Early Reaction, Inhibition and Late Action (SERIA) model explains our data better than PRO-Stop-Antisaccade (PROSA) that does not incorporate a late decision process.

Abstract

Neuropsychological studies indicate that healthy aging is associated with a decline of inhibitory control of attentional and behavioral systems. A widely accepted measure of inhibitory control is the antisaccade task that requires both the inhibition of a reflexive saccadic response toward a visual target and the initiation of a voluntary eye movement in the opposite direction. To better understand the nature of age-related differences in inhibitory control, we evaluated antisaccade task performance in 78 younger (20-35 years) and 78 older (60-80 years) participants. In order to provide reliable estimates of inhibitory control for individual subjects, we investigated test-retest reliability of the reaction time, error rate, saccadic gain, and peak saccadic velocity and further estimated latent, not directly observable processed contributing to changes in the antisaccade task execution. The intraclass correlation coefficients (ICCs) for an older group of participants emerged as good to excellent for most of our antisaccade task measures. Furthermore, using Bayesian multivariate models, we inspected age-related differences in the performances of healthy younger and older participants. The older group demonstrated higher error rates, longer reaction times, significantly more inhibition failures, and late prosaccades as compared with young adults. The consequently lower ability of older adults to voluntarily inhibit saccadic responses has been interpreted as an indicator of age-related inhibitory control decline. Additionally, we performed a Bayesian model comparison of used computational models and concluded that the Stochastic Early Reaction, Inhibition and Late Action (SERIA) model explains our data better than PRO-Stop-Antisaccade (PROSA) that does not incorporate a late decision process.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Neuroscience Center Zurich
06 Faculty of Arts > Institute of Psychology
07 Faculty of Science > Institute of Mathematics
08 Research Priority Programs > Dynamics of Healthy Aging
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:2020
Deposited On:10 Nov 2020 18:33
Last Modified:08 Dec 2020 13:44
Publisher:Society for Neuroscience
ISSN:2373-2822
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1523/ENEURO.0459-19.2020
PubMed ID:32907833

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