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Efficacy and Safety of Abbreviated Eptifibatide Treatment in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention


Fischer, Florian; Buxy, Samriddhi; Kurz, David J; Eberli, Franz R; Senn, Oliver; Zbinden, Rainer; Held, Ulrike; Meyer, Matthias R (2021). Efficacy and Safety of Abbreviated Eptifibatide Treatment in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. American Journal of Cardiology, 139:15-21.

Abstract

The glycoprotein IIb/IIIa inhibitor eptifibatide, administered as bolus followed by infusion, is an adjunctive antithrombotic treatment during primary percutaneous coronary intervention (PCI) in selected patients with ST-segment elevation myocardial infarction (STEMI). Whether both bolus and infusion are necessary to improve outcomes is unknown. We hypothesized that primary PCI with eptifibatide bolus only is non-inferior to the conventional treatment (bolus and infusion) with regard to infarct size, while reducing bleeding complications. We analyzed 720 consecutive STEMI patients receiving eptifibatide bolus only or conventional treatment in an observational case-control study utilizing propensity score matching of clinical and intervention-specific confounders. Infarct size was estimated based on myocardial bound creatine kinase (CK-MB), creatine kinase (CK), and CK area under the curve (CK-AUC) values, with a pre-specified non-inferiority margin of 20%. Major bleeding was defined as type 2, 3 or 5 on the Bleeding Academic Research Consortium (BARC) classification. Eptifibatide bolus only was administered to 147 patients (20%), which were matched 1:1 to patients receiving conventional treatment. Based on peak CK-MB, CK and CK-AUC values, infarct size was -8.4% (95% CI [-31.2%, 14.4%]), -11.6% (95% CI [-33.5%, 10.3%]), and -13.9% (95% CI [-34.1%, 6.2%]) after eptifibatide bolus, respectively, reaching pre-specified non-inferiority compared to conventional treatment. Bolus treatment significantly reduced major bleeding complications (OR 0.48, 95% CI [0.30, 0.79]). In conclusion, eptifibatide given as abbreviated bolus only to selected STEMI patients undergoing primary PCI was non-inferior regarding infarct size and resulted in less bleeding complications compared to conventional bolus and infusion treatment.

Abstract

The glycoprotein IIb/IIIa inhibitor eptifibatide, administered as bolus followed by infusion, is an adjunctive antithrombotic treatment during primary percutaneous coronary intervention (PCI) in selected patients with ST-segment elevation myocardial infarction (STEMI). Whether both bolus and infusion are necessary to improve outcomes is unknown. We hypothesized that primary PCI with eptifibatide bolus only is non-inferior to the conventional treatment (bolus and infusion) with regard to infarct size, while reducing bleeding complications. We analyzed 720 consecutive STEMI patients receiving eptifibatide bolus only or conventional treatment in an observational case-control study utilizing propensity score matching of clinical and intervention-specific confounders. Infarct size was estimated based on myocardial bound creatine kinase (CK-MB), creatine kinase (CK), and CK area under the curve (CK-AUC) values, with a pre-specified non-inferiority margin of 20%. Major bleeding was defined as type 2, 3 or 5 on the Bleeding Academic Research Consortium (BARC) classification. Eptifibatide bolus only was administered to 147 patients (20%), which were matched 1:1 to patients receiving conventional treatment. Based on peak CK-MB, CK and CK-AUC values, infarct size was -8.4% (95% CI [-31.2%, 14.4%]), -11.6% (95% CI [-33.5%, 10.3%]), and -13.9% (95% CI [-34.1%, 6.2%]) after eptifibatide bolus, respectively, reaching pre-specified non-inferiority compared to conventional treatment. Bolus treatment significantly reduced major bleeding complications (OR 0.48, 95% CI [0.30, 0.79]). In conclusion, eptifibatide given as abbreviated bolus only to selected STEMI patients undergoing primary PCI was non-inferior regarding infarct size and resulted in less bleeding complications compared to conventional bolus and infusion treatment.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 Faculty of Medicine > University Hospital Zurich > Institute of General Practice
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Cardiology and Cardiovascular Medicine
Language:English
Date:1 January 2021
Deposited On:20 Nov 2020 06:17
Last Modified:26 Jan 2021 14:59
Publisher:Elsevier
ISSN:0002-9149
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.amjcard.2020.09.054
PubMed ID:33065082

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