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Rubbiani, Riccardo; Wu, Wenyu; Naik, Anu; Larocca, Michele; Schneider, Lukas; Padrutt, Roxane; Babu, Vipin; König, Christiane; Hinger, Doris; Maake, Caroline; Ferrari, Stefano; Gasser, Gilles; Spingler, Bernhard (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56(92):14373-14376.
Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Anatomy
04 Faculty of Medicine > Institute of Molecular Cancer Research 07 Faculty of Science > Institute of Molecular Cancer Research 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials Physical Sciences > Ceramics and Composites Physical Sciences > General Chemistry Physical Sciences > Surfaces, Coatings and Films Physical Sciences > Metals and Alloys Physical Sciences > Materials Chemistry |
| Uncontrolled Keywords: | Materials Chemistry, Electronic, Optical and Magnetic Materials, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Ceramics and Composites, Catalysis |
| Language: | English |
| Date: | 20 October 2020 |
| Deposited On: | 24 Nov 2020 15:33 |
| Last Modified: | 08 Mar 2025 04:41 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| OA Status: | Hybrid |
| Publisher DOI: | https://doi.org/10.1039/d0cc05196a |
| Project Information: |
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Rubbiani, Riccardo