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Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling


Rubbiani, Riccardo; Wu, Wenyu; Naik, Anu; Larocca, Michele; Schneider, Lukas; Padrutt, Roxane; Babu, Vipin; König, Christiane; Hinger, Doris; Maake, Caroline; Ferrari, Stefano; Gasser, Gilles; Spingler, Bernhard (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56(92):14373-14376.

Abstract

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.

Abstract

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research

07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:Materials Chemistry, Electronic, Optical and Magnetic Materials, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Ceramics and Composites, Catalysis
Language:English
Date:20 October 2020
Deposited On:24 Nov 2020 15:33
Last Modified:03 May 2021 15:23
Publisher:Royal Society of Chemistry
ISSN:1359-7345
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1039/d0cc05196a
Project Information:
  • : FunderSNSF
  • : Grant ID205321_159976
  • : Project TitleChemo- and Phototoxic Conjugates: On the Way to a More Efficient Photodynamic Therapy
  • : FunderEidgenössische Stipendienkommission für ausländische Studierende
  • : Grant ID
  • : Project TitleSwiss Government Excellence Scholarship
  • : FunderNovartis
  • : Grant ID
  • : Project TitleNovartis Foundation for Medical-Biological Research
  • : FunderH2020
  • : Grant ID681679
  • : Project TitleTowards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes
  • : FunderANR
  • : Grant IDANR-10-IDEX-0001-02
  • : Project TitleInvestissements d’ Avenir

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