Header

UZH-Logo

Maintenance Infos

Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid


Grammatico, P; Scarpa, S; Picardo, M; Steindl, Katharina; Nazzaro-Porro, M; Del Porto, G (1993). Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. Mutation research, 300(2):119-123.

Abstract

Azelaic acid (AzAc) is a C9 dicarboxylic acid which has recently been shown to have some therapeutic applications in skin diseases of different aetiologies. In order to study the in vitro activity of AzAc five human malignant melanoma primary cell cultures were treated for up to 60 days with 10 mM C9 2Na; the growth characteristics were defined by growth curve and the cytogenetics by Giemsa standard technique and GTG banding technique. Our data demonstrated an inhibition in replication of all five melanomas and the disappearance of the clones with chromosomal markers in four out of five melanomas after AzAc treatment.

Abstract

Azelaic acid (AzAc) is a C9 dicarboxylic acid which has recently been shown to have some therapeutic applications in skin diseases of different aetiologies. In order to study the in vitro activity of AzAc five human malignant melanoma primary cell cultures were treated for up to 60 days with 10 mM C9 2Na; the growth characteristics were defined by growth curve and the cytogenetics by Giemsa standard technique and GTG banding technique. Our data demonstrated an inhibition in replication of all five melanomas and the disappearance of the clones with chromosomal markers in four out of five melanomas after AzAc treatment.

Statistics

Citations

Dimensions.ai Metrics
3 citations in Web of Science®
7 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 25 Nov 2020
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Toxicology
Life Sciences > Genetics
Language:English
Date:July 1993
Deposited On:25 Nov 2020 17:43
Last Modified:24 May 2024 01:43
Publisher:Elsevier
ISSN:0027-5107
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/0165-1218(93)90129-2
PubMed ID:7685492