Header

UZH-Logo

Maintenance Infos

Changes in real-world treatment patterns for diabetic macular oedema from 2009 to 2019 and 5-year outcomes: Data from the Fight Retinal Blindness! Registry


Biechl, Anne C; Bhandari, Sanjeeb; Nguyen, Vuong; Arnold, Jennifer J; Young, Stephanie; Fraser-Bell, Samantha; Mehta, Hemal; Gillies, Mark; Barthelmes, Daniel (2020). Changes in real-world treatment patterns for diabetic macular oedema from 2009 to 2019 and 5-year outcomes: Data from the Fight Retinal Blindness! Registry. Clinical & Experimental Ophthalmology, 48(6):802-812.

Abstract

IMPORTANCE
Evaluating the treatment outcomes of diabetic macular oedema (DMO) in routine clinical practice provides data for comparison with those of clinical trials.

BACKGROUND
Phase 3 clinical trials of vascular endothelial growth factor (VEGF) inhibitors for DMO have reported significant improvements in visual acuity (VA) not previously reported with laser and steroid treatments.

DESIGN
Retrospective analysis of observational data from routine clinical practice.

PARTICIPANTS
Eyes receiving treatments for DMO tracked in the Fight Retinal Blindness! Registry.

METHODS
We analysed 510 eyes (347 patients) that started DMO treatment between 2009 and 2014.

MAIN OUTCOME MEASURES
Changes in DMO treatment patterns and mean change in VA (letters logMAR) and central subfield thickness (CST) 5 years after starting treatment.

RESULTS
Treatment choice for DMO changed to predominantly VEGF inhibitors from 2009 to 2014. A total of 238 eyes (47%) were followed for at least 5 years. The mean VA at the start of treatment improved from 2009 (58 letters) to 2014 (68 letters) while mean VA change at 5 years were + 4.5 and + 5.3 letters for eyes starting treatment in 2009 and 2014, respectively. The mean CST dropped from 401 μm at baseline to 314 μm at 5 years. Eyes received a median of four injections in the first, two in the second, third and fourth and three in the fifth years.

CONCLUSIONS AND RELEVANCE
Changing the treatment of DMO from macular laser and intravitreal triamcinolone to VEGF inhibitors from 2011 onwards was associated with better VA outcomes, part of which were due to better VA at the start of treatment. The outcomes of treatment in eyes in real-world practice were, however, worse than those reported by clinical trials, likely because they were undertreated.

Abstract

IMPORTANCE
Evaluating the treatment outcomes of diabetic macular oedema (DMO) in routine clinical practice provides data for comparison with those of clinical trials.

BACKGROUND
Phase 3 clinical trials of vascular endothelial growth factor (VEGF) inhibitors for DMO have reported significant improvements in visual acuity (VA) not previously reported with laser and steroid treatments.

DESIGN
Retrospective analysis of observational data from routine clinical practice.

PARTICIPANTS
Eyes receiving treatments for DMO tracked in the Fight Retinal Blindness! Registry.

METHODS
We analysed 510 eyes (347 patients) that started DMO treatment between 2009 and 2014.

MAIN OUTCOME MEASURES
Changes in DMO treatment patterns and mean change in VA (letters logMAR) and central subfield thickness (CST) 5 years after starting treatment.

RESULTS
Treatment choice for DMO changed to predominantly VEGF inhibitors from 2009 to 2014. A total of 238 eyes (47%) were followed for at least 5 years. The mean VA at the start of treatment improved from 2009 (58 letters) to 2014 (68 letters) while mean VA change at 5 years were + 4.5 and + 5.3 letters for eyes starting treatment in 2009 and 2014, respectively. The mean CST dropped from 401 μm at baseline to 314 μm at 5 years. Eyes received a median of four injections in the first, two in the second, third and fourth and three in the fifth years.

CONCLUSIONS AND RELEVANCE
Changing the treatment of DMO from macular laser and intravitreal triamcinolone to VEGF inhibitors from 2011 onwards was associated with better VA outcomes, part of which were due to better VA at the start of treatment. The outcomes of treatment in eyes in real-world practice were, however, worse than those reported by clinical trials, likely because they were undertreated.

Statistics

Citations

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Ophthalmology
Language:English
Date:August 2020
Deposited On:01 Dec 2020 15:33
Last Modified:02 Dec 2020 21:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1442-6404
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/ceo.13781
PubMed ID:32383527

Download

Full text not available from this repository.
View at publisher

Get full-text in a library