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Preoperative neurodevelopment of children with moyamoya angiopathy


Serra, Sabina; Kugler, Julietta; Hug, Martina; Hackenberg, Annette; Latal, Beatrice; Khan, Nadia (2021). Preoperative neurodevelopment of children with moyamoya angiopathy. Developmental Medicine and Child Neurology, 63(2):218-225.

Abstract

Aim: To preoperatively assess the neurodevelopment of a predominantly white population of children with moyamoya angiopathy (MMA).

Method: Assessments of 40 children with MMA (24 females, 16 males; mean age 6y 11mo, range 20mo-16y) included tests for non-verbal IQ and fine motor skills, and questionnaires on quality of life, behaviour, and executive functions. The Paediatric Stroke Outcome Measure (PSOM) score was evaluated by a paediatric neurologist.

Results: Children with MMA had significantly lower non-verbal IQ scores (mean IQ 92.1, SD 19.6, p=0.015) and fine motor skills (z-score -1.84, p=0.004) than population norms. Patients with posterior cerebral artery (PCA) involvement had poorer non-verbal IQ scores than those without (79.6, SD 24.6 vs 95.2, SD 17.2, p=0.042). Higher PSOM scores were related to lower non-verbal IQ scores (Spearman's rank correlation coefficient -0.43, p=0.006), while the presence of stroke, bilaterality, disease versus syndrome, and age at diagnosis had no significant effect on non-verbal IQ. Quality of life, behaviour, and executive functions were in the typically developing range.

Interpretation: Children with MMA are more likely to manifest intellectual and fine motor skill impairment before surgical intervention. PCA involvement is an additional risk factor for lower non-verbal IQ.

Abstract

Aim: To preoperatively assess the neurodevelopment of a predominantly white population of children with moyamoya angiopathy (MMA).

Method: Assessments of 40 children with MMA (24 females, 16 males; mean age 6y 11mo, range 20mo-16y) included tests for non-verbal IQ and fine motor skills, and questionnaires on quality of life, behaviour, and executive functions. The Paediatric Stroke Outcome Measure (PSOM) score was evaluated by a paediatric neurologist.

Results: Children with MMA had significantly lower non-verbal IQ scores (mean IQ 92.1, SD 19.6, p=0.015) and fine motor skills (z-score -1.84, p=0.004) than population norms. Patients with posterior cerebral artery (PCA) involvement had poorer non-verbal IQ scores than those without (79.6, SD 24.6 vs 95.2, SD 17.2, p=0.042). Higher PSOM scores were related to lower non-verbal IQ scores (Spearman's rank correlation coefficient -0.43, p=0.006), while the presence of stroke, bilaterality, disease versus syndrome, and age at diagnosis had no significant effect on non-verbal IQ. Quality of life, behaviour, and executive functions were in the typically developing range.

Interpretation: Children with MMA are more likely to manifest intellectual and fine motor skill impairment before surgical intervention. PCA involvement is an additional risk factor for lower non-verbal IQ.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Life Sciences > Developmental Neuroscience
Health Sciences > Neurology (clinical)
Uncontrolled Keywords:Pediatrics, Perinatology, and Child Health, Developmental Neuroscience, Clinical Neurology
Language:English
Date:1 February 2021
Deposited On:01 Dec 2020 16:38
Last Modified:28 Feb 2021 08:14
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0012-1622
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/dmcn.14708
PubMed ID:33098576

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