Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

DDOS: due to massive botnet requests against our ‘Advanced Search’ we have restricted access to UZH (local and VPN). Thank you for your understanding.

Definition and validation of a radiomics signature for loco-regional tumour control in patients with locally advanced head and neck squamous cell carcinoma

Rabasco Meneghetti, Asier; Zwanenburg, Alex; Leger, Stefan; Leger, Karoline; Troost, Esther G C; Linge, Annett; Lohaus, Fabian; Schreiber, Andreas; Kalinauskaite, Goda; Tinhofer, Inge; Guberina, Nika; Guberina, Maja; Balermpas, Panagiotis; von der Grün, Jens; Ganswindt, Ute; Belka, Claus; Peeken, Jan C; Combs, Stephanie E; Böke, Simon; Zips, Daniel; Krause, Mechthild; Baumann, Michael; Löck, Steffen (2021). Definition and validation of a radiomics signature for loco-regional tumour control in patients with locally advanced head and neck squamous cell carcinoma. Clinical and Translational Radiation Oncology, 26(2021):62-70.

Abstract

Purpose: To develop and validate a CT-based radiomics signature for the prognosis of loco-regional tumour control (LRC) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated by primary radiochemotherapy (RCTx) based on retrospective data from 6 partner sites of the German Cancer Consortium - Radiation Oncology Group (DKTK-ROG).
Material and methods: Pre-treatment CT images of 318 patients with locally advanced HNSCC were col-lected. Four-hundred forty-six features were extracted from each primary tumour volume and then fil-tered through stability analysis and clustering. First, a baseline signature was developed from demographic and tumour-associated clinical parameters. This signature was then supplemented by CT imaging features. A final signature was derived using repeated 3-fold cross-validation on the discovery cohort. Performance in external validation was assessed by the concordance index (C-Index). Furthermore, calibration and patient stratification in groups with low and high risk for loco-regional recurrence were analysed.
Results: For the clinical baseline signature, only the primary tumour volume was selected. The final sig-nature combined the tumour volume with two independent radiomics features. It achieved moderately

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Health Sciences > Radiology, Nuclear Medicine and Imaging
Uncontrolled Keywords:HNSCC; Radiomics; Validation; Biomarker; Machine learning; Loco-regional control
Language:English
Date:November 2021
Deposited On:08 Dec 2020 16:19
Last Modified:05 Jun 2025 03:47
Publisher:Elsevier
ISSN:2405-6308
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.ctro.2020.11.011
Download PDF  'Definition and validation of a radiomics signature for loco-regional tumour control in patients with locally advanced head and neck squamous cell carcinoma'.
Preview
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
11 citations in Web of Science®
11 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

35 downloads since deposited on 08 Dec 2020
6 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications