Meier, Anita F; Fraefel, Cornel; Seyffert, Michael (2020). The interplay between adeno-associated virus and its helper viruses. Viruses, 12(6):662.
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Institute of Virology |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Health Sciences > Infectious Diseases
Life Sciences > Virology |
| Uncontrolled Keywords: | Virology, Infectious Diseases |
| Language: | English |
| Date: | 19 June 2020 |
| Deposited On: | 11 Jan 2021 16:28 |
| Last Modified: | 25 Sep 2023 01:39 |
| Publisher: | MDPI Publishing |
| ISSN: | 1999-4915 |
| OA Status: | Gold |
| Free access at: | PubMed ID. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.3390/v12060662 |
| PubMed ID: | 32575422 |
Meier, Anita F