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Fundamentally altered global- and microstate EEG characteristics in Huntington’s disease


Faber, Pascal L; Milz, Patricia; Reininghaus, Eva Z; Mörkl, Sabrina; Holl, Anna K; Kapfhammer, Hans-Peter; Pascual-Marqui, Roberto D; Kochi, Kieko; Achermann, Peter; Painold, Annamaria (2021). Fundamentally altered global- and microstate EEG characteristics in Huntington’s disease. Clinical Neurophysiology, 132(1):13-22.

Abstract

Objective: Huntington’s disease (HD) is characterized by psychiatric, cognitive, and motor disturbances. The study aimed to determine electroencephalography (EEG) global state and microstate changes in HD and their relationship with cognitive and behavioral impairments.
Methods: EEGs from 20 unmedicated HD patients and 20 controls were compared using global state properties (connectivity and dimensionality) and microstate properties (EEG microstate analysis). For four microstate classes (A, B, C, D), three parameters were computed: duration, occurrence, coverage. Global- and microstate properties were compared between groups and correlated with cognitive test scores for patients.
Results: Global state analysis showed reduced connectivity in HD and an increasing dimensionality with increasing HD severity. Microstate analysis revealed parameter increases for classes A and B (coverage), decreases for C (occurrence) and D (coverage and occurrence). Disease severity and poorer test performances correlated with parameter increases for class A (coverage and occurrence), decreases for C (coverage and duration) and a dimensionality increase.
Conclusions: Global state changes may reflect higher functional dissociation between brain areas and the complex microstate changes possibly the widespread neuronal death and corresponding functional deficits in brain regions associated with HD symptomatology.
Significance: Combining global- and microstate analyses can be useful for a better understanding of progressive brain deterioration in HD.

Abstract

Objective: Huntington’s disease (HD) is characterized by psychiatric, cognitive, and motor disturbances. The study aimed to determine electroencephalography (EEG) global state and microstate changes in HD and their relationship with cognitive and behavioral impairments.
Methods: EEGs from 20 unmedicated HD patients and 20 controls were compared using global state properties (connectivity and dimensionality) and microstate properties (EEG microstate analysis). For four microstate classes (A, B, C, D), three parameters were computed: duration, occurrence, coverage. Global- and microstate properties were compared between groups and correlated with cognitive test scores for patients.
Results: Global state analysis showed reduced connectivity in HD and an increasing dimensionality with increasing HD severity. Microstate analysis revealed parameter increases for classes A and B (coverage), decreases for C (occurrence) and D (coverage and occurrence). Disease severity and poorer test performances correlated with parameter increases for class A (coverage and occurrence), decreases for C (coverage and duration) and a dimensionality increase.
Conclusions: Global state changes may reflect higher functional dissociation between brain areas and the complex microstate changes possibly the widespread neuronal death and corresponding functional deficits in brain regions associated with HD symptomatology.
Significance: Combining global- and microstate analyses can be useful for a better understanding of progressive brain deterioration in HD.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > The KEY Institute for Brain-Mind Research
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Sensory Systems
Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Sensory Systems, Neurology, Clinical Neurology
Language:English
Date:1 January 2021
Deposited On:16 Dec 2020 14:10
Last Modified:17 Dec 2020 21:01
Publisher:Elsevier
ISSN:1388-2457
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.clinph.2020.10.006
PubMed ID:33249251

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