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Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats

Khera, Nupur; Ghayor, Chafik; Lindholm, Anna K; Pavlova, Ekaterina; Atanassova, Nina; Weber, Franz E (2020). Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats. Frontiers in Physiology, 11:601084.

Abstract

Development of an effective male contraceptive agent remains a challenge. The present study evaluates the potential of N, N-Dimethylacetamide (DMA), a FDA approved excipient as a male contraceptive agent. Male Sprague Dawley rats injected with DMA for a period of 8 weeks (one injection per week) showed a significant alteration of reproductive parameters. Furthermore, DMA treated animals showed complete infertility in a dose dependent manner, as no pups were born despite proper mating between females and DMA treated males. However, stopping the DMA treatment for a period of 8 weeks (after the initial treatment) restored the reproductive parameters to normal. Moreover, the fertility was resumed to normal as pups were born in the groups where DMA treatment was halted after initial DMA treatment. All these changes had no effect on the level of reproductive hormones FSH, LH and testosterone. Taken together, our results indicate that DMA acts in a reversible and non-hormonal manner to achieve contraception in rats. Therefore, repurposing the use of DMA could lead in a short time to an inexpensive and safer male contraceptive option.

Keywords: BET inhibitor; bromodomain (BRD); excipient; male contraception; rat; reproduction.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Cranio-Maxillofacial Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Physiology
Language:English
Date:10 November 2020
Deposited On:17 Dec 2020 08:09
Last Modified:24 Oct 2024 01:38
Publisher:Frontiers Research Foundation
ISSN:1664-042X
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fphys.2020.601084
PubMed ID:33240111
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