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Antipsychotic Overdosing and Polypharmacy in Schizophrenic Delinquents Explored


Günther, M P; Kirchebner, Johannes; Kling, S; Lau, Steffen (2020). Antipsychotic Overdosing and Polypharmacy in Schizophrenic Delinquents Explored. International Journal of Offender Therapy and Comparative Criminology, 64(9):938-952.

Abstract

A logistic regression model for 289 cases of schizophrenic offenders in a Swiss forensic hospital between 1995 and 2016 revealed the following factors for above average levels of antipsychotic overdosing and polypharmacy: Odds for overdosing increased in absence of a personality disorder (237%), for each point increase in emotional withdrawal (63.5%) and motor retardation (71.7%), and decreased for poor rapport (42.3%) recorded at admission. Odds for polypharmacy increased with complaints about physicians (157%), for each point increase in IQ (3.6%; range = 65–131, M = 92, SD = 14), reduction of the security level of the ward (36.8%; four levels), and for each point increase in poor attention (27.6%) at admission. It decreased with each previous conviction (10.9%; range = 1–21, M = 3, SD = 2), breaking of rules (46.4%) and the administration of compulsory measures (55.7%) on the ward, a poor legal prognosis (29.4%, four levels), and each point increase in grandiosity (40.3%), passive social withdrawal (42.3%), and depressive symptoms (38.7%) at admission.

Abstract

A logistic regression model for 289 cases of schizophrenic offenders in a Swiss forensic hospital between 1995 and 2016 revealed the following factors for above average levels of antipsychotic overdosing and polypharmacy: Odds for overdosing increased in absence of a personality disorder (237%), for each point increase in emotional withdrawal (63.5%) and motor retardation (71.7%), and decreased for poor rapport (42.3%) recorded at admission. Odds for polypharmacy increased with complaints about physicians (157%), for each point increase in IQ (3.6%; range = 65–131, M = 92, SD = 14), reduction of the security level of the ward (36.8%; four levels), and for each point increase in poor attention (27.6%) at admission. It decreased with each previous conviction (10.9%; range = 1–21, M = 3, SD = 2), breaking of rules (46.4%) and the administration of compulsory measures (55.7%) on the ward, a poor legal prognosis (29.4%, four levels), and each point increase in grandiosity (40.3%), passive social withdrawal (42.3%), and depressive symptoms (38.7%) at admission.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pathology and Forensic Medicine
Social Sciences & Humanities > Arts and Humanities (miscellaneous)
Social Sciences & Humanities > Applied Psychology
Uncontrolled Keywords:Applied Psychology, Pathology and Forensic Medicine, Arts and Humanities (miscellaneous), antipsychotic dosing, forensic psychiatry, evidence-based treatment of schizophrenia, schizophrenic delinquents, antipsychotic polypharmacy
Language:English
Date:1 July 2020
Deposited On:30 Dec 2020 12:34
Last Modified:31 Dec 2020 21:00
Publisher:Sage Publications
ISSN:0306-624X
OA Status:Closed
Publisher DOI:https://doi.org/10.1177/0306624x19895903

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