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Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions


Jumeau, Raphael; Ozsahin, Mahmut; Schwitter, Juerg; Elicin, Olgun; Reichlin, Tobias; Roten, Laurent; Andratschke, Nicolaus; Mayinger, Michael; Saguner, Ardan M; Steffel, Jan; Blanck, Oliver; Vozenin, Marie-Catherine; Moeckli, Raphael; Zeverino, Michele; Vallet, Véronique; Herrera-Siklody, Claudia; Pascale, Patrizio; Bourhis, Jean; Pruvot, Etienne (2020). Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions. Frontiers in cardiovascular medicine, 7(108):1-11.

Abstract

Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This review presents the basic underlying principles, proof of concept, and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation.

Abstract

Ventricular tachycardia (VT) caused by myocardial scaring bears a significant risk of mortality and morbidity. Antiarrhythmic drug therapy (AAD) and catheter ablation remain the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This review presents the basic underlying principles, proof of concept, and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Cardiology and Cardiovascular Medicine
Uncontrolled Keywords:ablation; noninvasive; radiotherapy; stereotactic radiotherapy; ventricular tachycardia
Language:English
Date:25 June 2020
Deposited On:07 Jan 2021 07:50
Last Modified:23 Feb 2024 02:56
Publisher:Frontiers Research Foundation
ISSN:2297-055X
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fcvm.2020.00108
PubMed ID:32671101
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)