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Biology and dynamics of B cells in the context of IgE‐mediated food allergy


Satitsuksanoa, Pattraporn; Daanje, Monique; Akdis, Mübeccel; Boyd, Scott D; van de Veen, Willem (2020). Biology and dynamics of B cells in the context of IgE‐mediated food allergy. Allergy:Epub ahead of print.

Abstract

An increasing number of people suffer from IgE‐mediated food allergies. The immunological mechanisms that cause IgE‐mediated food allergy have been extensively studied. B cells play a key role in the development of IgE‐mediated food allergies through the production of allergen‐specific antibodies. While this particular function of B cells has been known for many years, we still do not fully understand the mechanisms that regulate the induction and maintenance of allergen‐specific IgE production. It is still not fully understood where in the body IgE class switch recombination of food allergen‐specific B cells occurs, and what processes are involved in the immunological memory of allergen‐specific IgE responses. B cells can also contribute to the regulation of allergen‐specific immune responses through other mechanisms such as antigen presentation and cytokine production. Recent technological advances have enabled highly detailed analysis of small subsets of B cells down to the single‐cell level. In this review, we provide an overview of the current knowledge on the biology of B cells in relation to IgE‐mediated food allergies.

Abstract

An increasing number of people suffer from IgE‐mediated food allergies. The immunological mechanisms that cause IgE‐mediated food allergy have been extensively studied. B cells play a key role in the development of IgE‐mediated food allergies through the production of allergen‐specific antibodies. While this particular function of B cells has been known for many years, we still do not fully understand the mechanisms that regulate the induction and maintenance of allergen‐specific IgE production. It is still not fully understood where in the body IgE class switch recombination of food allergen‐specific B cells occurs, and what processes are involved in the immunological memory of allergen‐specific IgE responses. B cells can also contribute to the regulation of allergen‐specific immune responses through other mechanisms such as antigen presentation and cytokine production. Recent technological advances have enabled highly detailed analysis of small subsets of B cells down to the single‐cell level. In this review, we provide an overview of the current knowledge on the biology of B cells in relation to IgE‐mediated food allergies.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Uncontrolled Keywords:Immunology, Immunology and Allergy
Language:English
Date:22 December 2020
Deposited On:11 Jan 2021 10:07
Last Modified:17 Jan 2021 08:53
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0105-4538
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/all.14684
PubMed ID:33274454
Project Information:
  • : FunderSNSF
  • : Grant ID310030_179428
  • : Project TitleRegulation of immune response by antigen-specific regulatory and effector memory B cells

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