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Microbial Colonization From the Fetus to Early Childhood—A Comprehensive Review


Senn, Viola; Bassler, Dirk; Choudhury, Rashikh; Scholkmann, Felix; Righini-Grunder, Franziska; Vuille-dit-Bile, Raphael N; Restin, Tanja (2020). Microbial Colonization From the Fetus to Early Childhood—A Comprehensive Review. Frontiers in Cellular and Infection Microbiology, 10:573735.

Abstract

The development of the neonatal gastrointestinal tract microbiota remains a poorly understood process. The interplay between neonatal (gestational age, genetic background), maternal (mode of delivery, nutritional status) and environmental factors (antibiotic exposure, available nutrition) are thought to influence microbial colonization, however, the exact mechanisms are unclear. Derangements in this process likely contribute to various gastrointestinal diseases including necrotizing enterocolitis and inflammatory bowel disease. As such, enhanced understanding of microbiota development may hold the key to significantly reduce the burden of gastrointestinal disease in the pediatric population. The most debatable topics during microbial seeding and possible future treatment approaches will be highlighted in this review.

Abstract

The development of the neonatal gastrointestinal tract microbiota remains a poorly understood process. The interplay between neonatal (gestational age, genetic background), maternal (mode of delivery, nutritional status) and environmental factors (antibiotic exposure, available nutrition) are thought to influence microbial colonization, however, the exact mechanisms are unclear. Derangements in this process likely contribute to various gastrointestinal diseases including necrotizing enterocolitis and inflammatory bowel disease. As such, enhanced understanding of microbiota development may hold the key to significantly reduce the burden of gastrointestinal disease in the pediatric population. The most debatable topics during microbial seeding and possible future treatment approaches will be highlighted in this review.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Microbiology
Life Sciences > Immunology
Health Sciences > Microbiology (medical)
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Immunology, Microbiology (medical), Microbiology, Infectious Diseases, fetus; infant; microbiome; microbiota; newborn
Language:English
Date:30 October 2020
Deposited On:12 Jan 2021 16:43
Last Modified:24 Jun 2024 01:41
Publisher:Frontiers Research Foundation
ISSN:2235-2988
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fcimb.2020.573735
PubMed ID:33194813
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)