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Dynamic time domain near-infrared optical tomography based on a SPAD camera


Jiang, Jingjing; Di Costanzo Mata, Aldo; Lindner, Scott; Charbon, Edoardo; Wolf, Martin; Kalyanov, Alexander (2020). Dynamic time domain near-infrared optical tomography based on a SPAD camera. Biomedical Optics Express, 11(10):5470.

Abstract

In many clinical applications it is relevant to observe dynamic changes in oxygenation. Therefore the ability of dynamic imaging with time domain (TD) near-infrared optical tomography (NIROT) will be important. But fast imaging is a challenge. The data acquisition of our handheld TD NIROT system based on single photon avalanche diode (SPAD) camera and 11 light sources was consequently accelerated. We tested the system on a diffusive medium simulating tissue with a moving object embedded. With 3D image reconstruction, the moving object was correctly located using only 0.2 s exposure time per source.

Abstract

In many clinical applications it is relevant to observe dynamic changes in oxygenation. Therefore the ability of dynamic imaging with time domain (TD) near-infrared optical tomography (NIROT) will be important. But fast imaging is a challenge. The data acquisition of our handheld TD NIROT system based on single photon avalanche diode (SPAD) camera and 11 light sources was consequently accelerated. We tested the system on a diffusive medium simulating tissue with a moving object embedded. With 3D image reconstruction, the moving object was correctly located using only 0.2 s exposure time per source.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Biotechnology
Physical Sciences > Atomic and Molecular Physics, and Optics
Uncontrolled Keywords:Biotechnology, Atomic and Molecular Physics, and Optics
Language:English
Date:1 October 2020
Deposited On:12 Jan 2021 17:09
Last Modified:02 Feb 2021 22:10
Publisher:Optical Society of America
ISSN:2156-7085
OA Status:Green
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1364/boe.399387
PubMed ID:33149964
Project Information:
  • : FunderSNSF
  • : Grant ID320030_159490
  • : Project TitleBeyond individual brain activity: Assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning

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