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Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography


Ren, Wuwei; Jiang, Jingjing; Di Costanzo Mata, Aldo; Kalyanov, Alexander; Ripoll, Jorge; Lindner, Scott; Charbon, Edoardo; Zhang, Chao; Rudin, Markus; Wolf, Martin (2020). Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography. Optics Express, 28(7):9860-9874.

Abstract

Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the deviation of the assumed optical properties from the actual values. In this work, we improved the accuracy of the initial optical properties required for FMT using a new-generation time-domain (TD) near-infrared optical tomography (NIROT) system, which effectively decouples scattering and absorption coefficients. We proposed a multimodal paradigm combining TD-NIROT and continuous-wave (CW) FMT. Both numerical simulation and experiments were performed on a heterogeneous phantom containing a fluorescent inclusion. The results demonstrate significant improvement in the FMT reconstruction by taking the NIROT-derived optical properties as prior information. The multimodal method is attractive for preclinical studies and tumor diagnostics since both functional and molecular information can be obtained.

Abstract

Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the deviation of the assumed optical properties from the actual values. In this work, we improved the accuracy of the initial optical properties required for FMT using a new-generation time-domain (TD) near-infrared optical tomography (NIROT) system, which effectively decouples scattering and absorption coefficients. We proposed a multimodal paradigm combining TD-NIROT and continuous-wave (CW) FMT. Both numerical simulation and experiments were performed on a heterogeneous phantom containing a fluorescent inclusion. The results demonstrate significant improvement in the FMT reconstruction by taking the NIROT-derived optical properties as prior information. The multimodal method is attractive for preclinical studies and tumor diagnostics since both functional and molecular information can be obtained.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Atomic and Molecular Physics, and Optics
Uncontrolled Keywords:Atomic and Molecular Physics, and Optics
Language:English
Date:30 March 2020
Deposited On:12 Jan 2021 17:35
Last Modified:13 Feb 2021 17:21
Publisher:Optical Society of America
ISSN:1094-4087
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1364/oe.385392
PubMed ID:32225585
Project Information:
  • : FunderSNSF
  • : Grant ID320030_159490
  • : Project TitleBeyond individual brain activity: Assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning
  • : FunderSNSF
  • : Grant ID40B1-0_178262
  • : Project TitleKaleiBox: a portable device for multifunctional fluorescence tomography
  • : FunderH2020
  • : Grant ID801347
  • : Project TitleSENSITIVE - Early Detection of cancer onset based on sensing field cancerization at the organ level

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