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Histopathologic Evaluation of Intralabyrinthine Schwannoma

Bagattini, Michael; Quesnel, Alicia M; Röösli, Christof (2021). Histopathologic Evaluation of Intralabyrinthine Schwannoma. Audiology and Neurotology, 26(4):265-272.

Abstract

Objectives: The aim of this study is to perform a histopathologic analysis of temporal bones with an intralabyrinthine schwannoma (ILS) in order to characterize its extension. Methods: Archival temporal bones with a diagnosis of sporadic schwannoma were identified. Both symptomatic and occult nonoperated ILS were included for further analysis. Results: A total of 6 ILS were identified, with 4 intracochlear and 2 intravestibular schwannomas. All intracochlear schwannomas involved the osseous spiral lamina, with 2 extending into the modiolus. The intravestibular schwannomas were limited to the vestibule, but growth into the bone next to the crista of the lateral semicircular canal was observed in 1 patient. Conclusions: Complete removal of an ILS may require partial removal of the modiolus or bone surrounding the crista ampullaris as an ILS may extend into these structures, risking damage of the neuronal structures. Due to the slow growth of the ILS, it remains unclear if a complete resection is required with the risk of destroying neural structures hindering hearing rehabilitation with a cochlear implant.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Health Sciences > Otorhinolaryngology
Life Sciences > Sensory Systems
Health Sciences > Speech and Hearing
Uncontrolled Keywords:Speech and Hearing, Physiology, Sensory Systems, Otorhinolaryngology
Language:English
Date:1 January 2021
Deposited On:20 Jan 2021 11:58
Last Modified:24 Sep 2024 01:36
Publisher:Karger
ISSN:1420-3030
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1159/000511634
Related URLs:https://www.zora.uzh.ch/id/eprint/213794/
PubMed ID:33352553
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