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Opto-E-Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience


Renz, Aline F; Lee, Jihyun; Tybrandt, Klas; Brzezinski, Maciej; Lorenzo, Dayra A; Cerra Cheraka, Mouna; Lee, Jaehong; Helmchen, Fritjof; Vörös, Janos; Lewis, Christopher M (2020). Opto-E-Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience. Advanced Healthcare Materials, 9(17):e2000814.

Abstract

Soft, stretchable materials hold great promise for the fabrication of biomedical devices due to their capacity to integrate gracefully with and conform to biological tissues. Conformal devices are of particular interest in the development of brain interfaces where rigid structures can lead to tissue damage and loss of signal quality over the lifetime of the implant. Interfaces to study brain function and dysfunction increasingly require multimodal access in order to facilitate measurement of diverse physiological signals that span the disparate temporal and spatial scales of brain dynamics. Here the Opto-e-Dura, a soft, stretchable, 16-channel electrocorticography array that is optically transparent is presented. Its compatibility with diverse optical and electrical readouts is demonstrated enabling multimodal studies that bridge spatial and temporal scales. The device is chronically stable for weeks, compatible with wide-field and 2-photon calcium imaging and permits the repeated insertion of penetrating multielectrode arrays. As the variety of sensors and effectors realizable on soft, stretchable substrates expands, similar devices that provide large-scale, multimodal access to the brain will continue to improve fundamental understanding of brain function.

Abstract

Soft, stretchable materials hold great promise for the fabrication of biomedical devices due to their capacity to integrate gracefully with and conform to biological tissues. Conformal devices are of particular interest in the development of brain interfaces where rigid structures can lead to tissue damage and loss of signal quality over the lifetime of the implant. Interfaces to study brain function and dysfunction increasingly require multimodal access in order to facilitate measurement of diverse physiological signals that span the disparate temporal and spatial scales of brain dynamics. Here the Opto-e-Dura, a soft, stretchable, 16-channel electrocorticography array that is optically transparent is presented. Its compatibility with diverse optical and electrical readouts is demonstrated enabling multimodal studies that bridge spatial and temporal scales. The device is chronically stable for weeks, compatible with wide-field and 2-photon calcium imaging and permits the repeated insertion of penetrating multielectrode arrays. As the variety of sensors and effectors realizable on soft, stretchable substrates expands, similar devices that provide large-scale, multimodal access to the brain will continue to improve fundamental understanding of brain function.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Physical Sciences > Biomaterials
Physical Sciences > Biomedical Engineering
Life Sciences > Pharmaceutical Science
Language:English
Date:September 2020
Deposited On:20 Jan 2021 13:02
Last Modified:27 Jan 2022 04:42
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:2192-2640
Additional Information:This is the peer reviewed version of the following article: Renz, A. F., Lee, J., Tybrandt, K., Brzezinski, M., Lorenzo, D. A., Cerra, M., Lee, J., Helmchen, F., Vörös, J., Lewis, C. M., Opto‐E‐Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience. Adv. Healthcare Mater. 2020, 9, 2000814, which has been published in final form at https://doi.org/10.1002/adhm.202000814. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. (http://www.wileyauthors.com/self-archiving)
OA Status:Green
Publisher DOI:https://doi.org/10.1002/adhm.202000814
PubMed ID:32691992

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