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Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study


Manoliu, Andrei; Sladky, Ronald; Scherpiet, Sigrid; Jäncke, Lutz; Kirschner, Matthias; Haugg, Amelie; Bolsinger, Julia; Kraehenmann, Rainer; Stämpfli, Philipp; Scharnowski, Frank; Herwig, Uwe; Seifritz, Erich; Brühl, Annette B (2021). Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study. Journal of Psychopharmacology, 35(1):100-102.

Abstract

The aim of this study was to investigate the effect of acute dopamine agonistic and antagonistic manipulation on the visual-cue induced blood oxygen level-dependent signal response in healthy volunteers. Seventeen healthy volunteers in a double-blind placebo-controlled cross-over design received either a dopamine antagonist, agonist or placebo and underwent functional magnetic resonance imaging. Using classical inference and Bayesian statistics, we found no effect of dopaminergic modulation on properties of visual-cue induced blood oxygen level-dependent signals in the visual cortex, particularly on distinct properties of the haemodynamic response function (amplitude, time-to-peak and width). Dopamine-related effects modulating the neurovascular coupling in the visual cortex might be negligible when measured via functional magnetic resonance imaging.

Abstract

The aim of this study was to investigate the effect of acute dopamine agonistic and antagonistic manipulation on the visual-cue induced blood oxygen level-dependent signal response in healthy volunteers. Seventeen healthy volunteers in a double-blind placebo-controlled cross-over design received either a dopamine antagonist, agonist or placebo and underwent functional magnetic resonance imaging. Using classical inference and Bayesian statistics, we found no effect of dopaminergic modulation on properties of visual-cue induced blood oxygen level-dependent signals in the visual cortex, particularly on distinct properties of the haemodynamic response function (amplitude, time-to-peak and width). Dopamine-related effects modulating the neurovascular coupling in the visual cortex might be negligible when measured via functional magnetic resonance imaging.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > Neuroscience Center Zurich
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Life Sciences > Pharmacology
Health Sciences > Psychiatry and Mental Health
Health Sciences > Pharmacology (medical)
Language:English
Date:January 2021
Deposited On:20 Jan 2021 12:55
Last Modified:21 Jan 2021 21:05
Publisher:Sage Publications
ISSN:0269-8811
OA Status:Closed
Publisher DOI:https://doi.org/10.1177/0269881120972341
PubMed ID:33307959
Project Information:
  • : FunderSNSF
  • : Grant IDP2SKP3_178107
  • : Project TitleDid you unlearn to experience pleasure? Towards a multimodal computational biomarker for the anhedonia dimension in depression
  • : FunderSNSF
  • : Grant IDBSSGI0_155915
  • : Project TitleTreatment of Human Brain Dysfunction with Neurofeedback.
  • : FunderSNSF
  • : Grant ID100014_178841
  • : Project TitleClosed-loop brain training
  • : FunderSNSF
  • : Grant ID32003B_166566
  • : Project TitleEnhancing functional connectivity in prefrontal networks to test and improve self-control mechanisms in decision-making
  • : FunderFoundation for Research in Science and the Humanities at the University of Zurich
  • : Grant IDSTWF-17-012
  • : Project Title
  • : FunderBaugarten Stiftung
  • : Grant ID
  • : Project Title

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