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Pheophorbide a may regulate Jasmonate signaling during dark-induced senescence

Aubry, Sylvain; Fankhauser, Niklaus; Ovinnikov, Serguei; Pružinská, Adriana; Stirnemann, Marina; Zienkiewicz, Krzysztof; Herrfurth, Cornelia; Feussner, Ivo; Hörtensteiner, Stefan (2020). Pheophorbide a may regulate Jasmonate signaling during dark-induced senescence. Plant Physiology, 182(2):776-791.

Abstract

Chlorophyll degradation is one of the most visible signs of leaf senescence. During senescence, chlorophyll is degraded in the multistep pheophorbide a oxygenase (PAO)/phyllobilin pathway. This pathway is tightly regulated at the transcriptional level, allowing coordinated and efficient remobilization of nitrogen toward sink organs. Using a combination of transcriptome and metabolite analyses during dark-induced senescence of Arabidopsis (Arabidopsis thaliana) mutants deficient in key steps of the PAO/phyllobilin pathway, we show an unanticipated role for one of the pathway intermediates, i.e. pheophorbide a Both jasmonic acid-related gene expression and jasmonic acid precursors specifically accumulated in pao1, a mutant deficient in PAO. We propose that pheophorbide a, the last intact porphyrin intermediate of chlorophyll degradation and a unique pathway "bottleneck," has been recruited as a signaling molecule of chloroplast metabolic status. Our work challenges the assumption that chlorophyll breakdown is merely a result of senescence, and proposes that the flux of pheophorbide a through the pathway acts in a feed-forward loop that remodels the nuclear transcriptome and controls the pace of chlorophyll degradation in senescing leaves.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Plant and Microbial Biology
07 Faculty of Science > Zurich-Basel Plant Science Center
Dewey Decimal Classification:580 Plants (Botany)
Scopus Subject Areas:Life Sciences > Physiology
Life Sciences > Genetics
Life Sciences > Plant Science
Uncontrolled Keywords:Plant Science, Genetics, Physiology
Language:English
Date:1 February 2020
Deposited On:22 Jan 2021 07:43
Last Modified:25 Oct 2024 01:35
Publisher:American Society of Plant Biologists
ISSN:0032-0889
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1104/pp.19.01115
PubMed ID:31753845
Project Information:
  • Funder: SNSF
  • Grant ID: 31003A_172977
  • Project Title: Diversity and evolution of the PAO/phyllobilin pathway of chlorophyll breakdown
  • Funder: SNSF
  • Grant ID: 31CP30_163504
  • Project Title: Molecular mechanisms of abiotic stress-induced senescence in plants
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