Huang, Yun; Bourquin, Jean-Pierre (2020). Targeting the oncogenic activity of TCF3-HLF in leukemia. Molecular, 7(3):1709391.
The oncogenic fusion transcription factor TCF3-HLF identifies an aggressive subtype of acute lymphoblastic leukemia. TCF3-HLF imposes a malignant program by activation of lineage-specific oncogenic enhancers. Among critical cofactors of the TCF3-HLF complex we identified EP300, which functional inhibition results in potent anti-leukemic activity by interference with the specific gene expression.
The oncogenic fusion transcription factor TCF3-HLF identifies an aggressive subtype of acute lymphoblastic leukemia. TCF3-HLF imposes a malignant program by activation of lineage-specific oncogenic enhancers. Among critical cofactors of the TCF3-HLF complex we identified EP300, which functional inhibition results in potent anti-leukemic activity by interference with the specific gene expression.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Molecular Medicine
Life Sciences > Cancer Research |
| Language: | English |
| Date: | 2020 |
| Deposited On: | 27 Jan 2021 10:06 |
| Last Modified: | 25 Nov 2023 02:46 |
| Publisher: | Taylor & Francis |
| ISSN: | 2372-3556 |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1080/23723556.2019.1709391 |
| PubMed ID: | 32391417 |
Huang, Yun