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Targeting the oncogenic activity of TCF3-HLF in leukemia


Huang, Yun; Bourquin, Jean-Pierre (2020). Targeting the oncogenic activity of TCF3-HLF in leukemia. Molecular, 7(3):1709391.

Abstract

The oncogenic fusion transcription factor TCF3-HLF identifies an aggressive subtype of acute lymphoblastic leukemia. TCF3-HLF imposes a malignant program by activation of lineage-specific oncogenic enhancers. Among critical cofactors of the TCF3-HLF complex we identified EP300, which functional inhibition results in potent anti-leukemic activity by interference with the specific gene expression.

Abstract

The oncogenic fusion transcription factor TCF3-HLF identifies an aggressive subtype of acute lymphoblastic leukemia. TCF3-HLF imposes a malignant program by activation of lineage-specific oncogenic enhancers. Among critical cofactors of the TCF3-HLF complex we identified EP300, which functional inhibition results in potent anti-leukemic activity by interference with the specific gene expression.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Medicine
Life Sciences > Cancer Research
Language:English
Date:2020
Deposited On:27 Jan 2021 10:06
Last Modified:28 Jan 2021 21:01
Publisher:Taylor & Francis
ISSN:2372-3556
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/23723556.2019.1709391
PubMed ID:32391417

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