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Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children


Uden, Theodor; Bertaina, Alice; Abrahamsson, Jonas; Ansari, Marc; Balduzzi, Adriana; Bourquin, Jean-Pierre; Gerhardt, Corinne; Bierings, Marc; Hasle, Henrik; Lankester, Arjan; Mischke, Kirsten; Moore, Andrew S; Nivison-Smith, Ian; Pieczonka, Anna; Peters, Christina; Sedlacek, Petr; Reinhardt, Dirk; Stein, Jerry; Versluys, Birgitta; Wachowiak, Jacek; Willems, Leen; Zimmermann, Martin; Locatelli, Franco; Sauer, Martin G (2020). Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children. British Journal of Haematology, 189(4):745-750.

Abstract

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

Abstract

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Hematology
Language:English
Date:May 2020
Deposited On:27 Jan 2021 10:08
Last Modified:28 Jan 2021 21:01
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0007-1048
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/bjh.16441
PubMed ID:32012224

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