Header

UZH-Logo

Maintenance Infos

SARS-CoV-2 Infection During Induction Chemotherapy in a Child With High-risk T-Cell Acute Lymphoblastic Leukemia (T-ALL)


Dantonello, Tobias M; Kartal-Kaess, Mutlu; Aebi, Christoph; Suter-Riniker, Franziska; Busch, Jasmin D; Kubetzko, Susanne; Bourquin, Jean-Pierre; Roessler, Jochen (2021). SARS-CoV-2 Infection During Induction Chemotherapy in a Child With High-risk T-Cell Acute Lymphoblastic Leukemia (T-ALL). Journal of Pediatric Hematology/Oncology, 43(6):e804-e807.

Abstract

The clinical course of SARS-CoV-2 infection (COVID-19) in children with hematologic malignancies is unclear. We describe the diagnosis, treatment and outcome of a 4-year-old boy with high-risk acute lymphoblastic leukemia and COVID-19. Regardless of immunosuppressive induction chemotherapy his symptoms remained moderate. He received only supportive treatment. Seroconversion occurred in a similar period as in immunocompetent adults. Despite prolonged myelosuppression he did neither acquire secondary infections nor did the treatment delay caused by the infection have a measurable negative impact on the residual disease of acute lymphoblastic leukemia. Intriguingly, residual leukemia even decreased even though he did not receive any antileukemic therapy.

Abstract

The clinical course of SARS-CoV-2 infection (COVID-19) in children with hematologic malignancies is unclear. We describe the diagnosis, treatment and outcome of a 4-year-old boy with high-risk acute lymphoblastic leukemia and COVID-19. Regardless of immunosuppressive induction chemotherapy his symptoms remained moderate. He received only supportive treatment. Seroconversion occurred in a similar period as in immunocompetent adults. Despite prolonged myelosuppression he did neither acquire secondary infections nor did the treatment delay caused by the infection have a measurable negative impact on the residual disease of acute lymphoblastic leukemia. Intriguingly, residual leukemia even decreased even though he did not receive any antileukemic therapy.

Statistics

Citations

Dimensions.ai Metrics
6 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 August 2021
Deposited On:27 Jan 2021 10:09
Last Modified:03 Mar 2022 02:02
Publisher:Lippincott Williams & Wilkins
ISSN:1077-4114
OA Status:Closed
Publisher DOI:https://doi.org/10.1097/MPH.0000000000001943
PubMed ID:32925396

Download

Full text not available from this repository.
View at publisher

Get full-text in a library