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Association between vitamin D and endometriosis: a systematic review


Kalaitzopoulos, Dimitrios Rafail; Lempesis, Ioannis G; Athanasaki, Florentia; Schizas, Dimitrios; Samartzis, Eleftherios Pierre; Kolibianakis, Efstratios M; Goulis, Dimitrios G (2020). Association between vitamin D and endometriosis: a systematic review. Hormones (Athens, Greece), 19(2):109-121.

Abstract

Background: Endometriosis is one of the most common gynecological diseases of reproductive age, with a prevalence of 5-10% and grave consequences for quality of life and fertility. Vitamin D (vit D), a classic regulator of plasma calcium concentration and skeleton mineralization, is also an effective modulator of the immune system. Several studies suggest that immunologic properties attributed to vit D along with vit D receptor (VDR) expression in reproductive tissues may be involved in the pathogenesis of endometriosis.

Objective: To systematically review the literature for the association between components of vit D metabolism and endometriosis.

Materials and methods: A systematic review of the literature published in the Medline and Cochrane Central databases was conducted for original research articles on humans, published in any language.

Results: Twenty-one studies were included in the systematic review. Among them, 12 examined the relationship of endometriosis with vit D metabolites, eight with vit D-binding protein (VDBP), three with VDR polymorphisms, and two with vit D regulatory enzymes. There are discrepancies between the outcomes of the available literature publications.

Conclusions: This is a systematic attempt to collect, evaluate, and present the known data on the association between vit D and endometriosis. Given the heterogeneity and the diversity of the present studies, more research is required to elucidate the association between vit D and endometriosis.

Abstract

Background: Endometriosis is one of the most common gynecological diseases of reproductive age, with a prevalence of 5-10% and grave consequences for quality of life and fertility. Vitamin D (vit D), a classic regulator of plasma calcium concentration and skeleton mineralization, is also an effective modulator of the immune system. Several studies suggest that immunologic properties attributed to vit D along with vit D receptor (VDR) expression in reproductive tissues may be involved in the pathogenesis of endometriosis.

Objective: To systematically review the literature for the association between components of vit D metabolism and endometriosis.

Materials and methods: A systematic review of the literature published in the Medline and Cochrane Central databases was conducted for original research articles on humans, published in any language.

Results: Twenty-one studies were included in the systematic review. Among them, 12 examined the relationship of endometriosis with vit D metabolites, eight with vit D-binding protein (VDBP), three with VDR polymorphisms, and two with vit D regulatory enzymes. There are discrepancies between the outcomes of the available literature publications.

Conclusions: This is a systematic attempt to collect, evaluate, and present the known data on the association between vit D and endometriosis. Given the heterogeneity and the diversity of the present studies, more research is required to elucidate the association between vit D and endometriosis.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Endocrinology, Diabetes and Metabolism
Uncontrolled Keywords:Endocrinology, Diabetes and Metabolism, General Medicine
Language:English
Date:1 June 2020
Deposited On:29 Jan 2021 12:36
Last Modified:30 Jan 2021 21:01
Publisher:Hellenic Endocrine Soc.
ISSN:1109-3099
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s42000-019-00166-w
PubMed ID:31863346

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