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Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study


Ren, Wuwei; Deán‐Ben, Xosé Luís; Augath, Mark‐Aurel; Razansky, Daniel (2021). Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study. Journal of Biophotonics, 14(2):e202000293.

Abstract

Optoacoustic tomography (OAT) and magnetic resonance imaging (MRI) provide highly complementary capabilities for anatomical and functional imaging of living organisms. Herein, we investigate on the feasibility of combining both modalities to render concurrent images. This was achieved by introducing a specifically‐designed copper‐shielded spherical ultrasound array into a preclinical MRI scanner. Phantom experiments revealed that the OAT probe caused minimal distortion in the MRI images, while synchronization of the laser and the MRI pulse sequence enabled defining artifact‐free acquisition windows for OAT. Good dynamic OAT contrast from superparamagnetic iron oxide nanoparticles, a commonly used agent for MRI contrast enhancement, was also observed. The hybrid OAT‐MRI system thus provides an excellent platform for cross‐validating functional readings of both modalities. Overall, this initial study serves to establish the technical feasibility of developing a hybrid OAT‐MRI system for biomedical research.

Abstract

Optoacoustic tomography (OAT) and magnetic resonance imaging (MRI) provide highly complementary capabilities for anatomical and functional imaging of living organisms. Herein, we investigate on the feasibility of combining both modalities to render concurrent images. This was achieved by introducing a specifically‐designed copper‐shielded spherical ultrasound array into a preclinical MRI scanner. Phantom experiments revealed that the OAT probe caused minimal distortion in the MRI images, while synchronization of the laser and the MRI pulse sequence enabled defining artifact‐free acquisition windows for OAT. Good dynamic OAT contrast from superparamagnetic iron oxide nanoparticles, a commonly used agent for MRI contrast enhancement, was also observed. The hybrid OAT‐MRI system thus provides an excellent platform for cross‐validating functional readings of both modalities. Overall, this initial study serves to establish the technical feasibility of developing a hybrid OAT‐MRI system for biomedical research.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Scopus Subject Areas:Physical Sciences > General Chemistry
Physical Sciences > General Materials Science
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Physical Sciences > General Engineering
Physical Sciences > General Physics and Astronomy
Uncontrolled Keywords:General Engineering, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Materials Science, General Chemistry
Language:English
Date:February 2021
Deposited On:01 Feb 2021 15:44
Last Modified:17 Feb 2021 02:14
Publisher:Wiley-VCH Verlag
ISSN:1864-063X
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/jbio.202000293
PubMed ID:33169918
Project Information:
  • : FunderSNSF
  • : Grant ID310030_192757
  • : Project TitleDevelopment of a hybrid scanner for concurrent magnetic resonance imaging, optoacoustic tomography and wide-field fluorescence

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