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Circulating neurotrophins and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and during sympathetic challenge: the SABPA study


von Känel, Roland; Hamer, Mark; Wentzel, Annemarie; Malan, Leoné (2021). Circulating neurotrophins and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and during sympathetic challenge: the SABPA study. Scientific Reports, 11:2297.

Abstract

Sympathetic activation may trigger acute coronary syndromes. We examined the relation between circulating neurotrophic factors and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and in response to acute mental stress to establish a brain–heart link. In 409 black and white South Africans, brain-derived neurotrophic factor (BDNF) and fibrinolytic measures were assessed at baseline. Glial cell-derived neurotrophic factor (GDNF), S100 calcium-binding protein (S100B), von Willebrand factor (VWF), fibrinogen and D-dimer were assessed at baseline and 10 min after the Stroop test. Neurotrophins were regressed on hemostatic measures adjusting for demographics, comorbidities, cardiometabolic factors and health behaviors. Higher baseline BDNF was associated with greater stress-induced increase in fibrinogen (<jats:italic>p</jats:italic> = 0.003) and lower D-dimer increase (<jats:italic>p</jats:italic> = 0.016). Higher baseline S100B was significantly associated with higher baseline VWF (<jats:italic>p</jats:italic> = 0.031) and lower fibrinogen increase (<jats:italic>p</jats:italic> = 0.048). Lower baseline GDNF was associated with higher baseline VWF (<jats:italic>p</jats:italic> = 0.035) but lower VWF increase (<jats:italic>p</jats:italic> = 0.001). Greater GDNF (<jats:italic>p</jats:italic> = 0.006) and S100B (<jats:italic>p</jats:italic> = 0.042) increases were associated with lower VWF increase. All associations showed small-to-moderate effect sizes. Neurotrophins and fibrinolytic factors showed no significant associations. The findings support the existence of a peripheral neurothrophin-hemostasis interaction of small-to-moderate clinical relevance. The implications for atherothrombotic cardiovascular disease need further exploration.

Abstract

Sympathetic activation may trigger acute coronary syndromes. We examined the relation between circulating neurotrophic factors and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and in response to acute mental stress to establish a brain–heart link. In 409 black and white South Africans, brain-derived neurotrophic factor (BDNF) and fibrinolytic measures were assessed at baseline. Glial cell-derived neurotrophic factor (GDNF), S100 calcium-binding protein (S100B), von Willebrand factor (VWF), fibrinogen and D-dimer were assessed at baseline and 10 min after the Stroop test. Neurotrophins were regressed on hemostatic measures adjusting for demographics, comorbidities, cardiometabolic factors and health behaviors. Higher baseline BDNF was associated with greater stress-induced increase in fibrinogen (<jats:italic>p</jats:italic> = 0.003) and lower D-dimer increase (<jats:italic>p</jats:italic> = 0.016). Higher baseline S100B was significantly associated with higher baseline VWF (<jats:italic>p</jats:italic> = 0.031) and lower fibrinogen increase (<jats:italic>p</jats:italic> = 0.048). Lower baseline GDNF was associated with higher baseline VWF (<jats:italic>p</jats:italic> = 0.035) but lower VWF increase (<jats:italic>p</jats:italic> = 0.001). Greater GDNF (<jats:italic>p</jats:italic> = 0.006) and S100B (<jats:italic>p</jats:italic> = 0.042) increases were associated with lower VWF increase. All associations showed small-to-moderate effect sizes. Neurotrophins and fibrinolytic factors showed no significant associations. The findings support the existence of a peripheral neurothrophin-hemostasis interaction of small-to-moderate clinical relevance. The implications for atherothrombotic cardiovascular disease need further exploration.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Klinik für Konsiliarpsychiatrie und Psychosomatik
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Multidisciplinary
Uncontrolled Keywords:Multidisciplinary
Language:English
Date:27 January 2021
Deposited On:03 Feb 2021 13:40
Last Modified:06 Feb 2021 04:33
Publisher:Nature Publishing Group
ISSN:2045-2322
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/s41598-021-81946-6
PubMed ID:33504912

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